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discounted EARLY registration ends Dec 31, 2014
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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Metabolic Modeling Tutorial
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Escherichia coli K-12 substr. MG1655 Reaction: 3.6.1.19/3.6.1.23

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.1.19 , 3.6.1.23

Enzymes and Genes:
pyrimidine deoxynucleoside triphosphate pyrophosphohydrolase Inferred from experiment : nudI
deoxyuridine triphosphatase Inferred from experiment : dut
nucleoside triphosphate pyrophosphohydrolase : mazG

In Pathway: superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) , pyrimidine deoxyribonucleotides de novo biosynthesis I , pyrimidine deoxyribonucleotides dephosphorylation , pyrimidine deoxyribonucleotides de novo biosynthesis II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name for 3.6.1.19: nucleoside-triphosphate diphosphatase

Enzyme Commission Synonyms for 3.6.1.19: nucleoside-triphosphate pyrophosphatase

Enzyme Commission Primary Name for 3.6.1.23: dUTP diphosphatase

Enzyme Commission Synonyms for 3.6.1.23: deoxyuridine-triphosphatase, dUTPase, dUTP pyrophosphatase, desoxyuridine 5'-triphosphate nucleotidohydrolase, desoxyuridine 5'-triphosphatase

Summary:
This reaction is part of pyrimidine nucleotide metabolism.

Enzyme Commission Summary for 3.6.1.19:
May be identical with EC 3.6.1.9 nucleotide diphosphatase.

Citations: [Chern69, Zhang02b, BERTANI63, Giroir87, GREENBERG62, Grindey71]

Gene-Reaction Schematic: ?

Instance reactions of [a nucleoside triphosphate + H2O → a nucleoside 5'-monophosphate + diphosphate + H+] (3.6.1.19):
i1: CTP + H2O → CMP + diphosphate + H+ (3.6.1.65)

i2: dATP + H2O → dAMP + diphosphate + H+ (3.6.1.19)

i3: dUTP + H2O → dUMP + diphosphate + H+ (3.6.1.19/3.6.1.23)
i4: dGTP + H2O → dGMP + diphosphate + H+ (3.6.1.19)

i5: dITP + H2O → dIMP + diphosphate + H+ (3.6.1.66)

i6: ITP + H2O → IMP + diphosphate + H+ (3.6.1.19)

i7: XTP + H2O → XMP + diphosphate + H+ (3.6.1.66)

i8: ATP + H2O → AMP + diphosphate + H+ (3.6.1.8)

i9: dTTP + H2O → dTMP + diphosphate + H+ (3.6.1.19)

i10: UTP + H2O → UMP + diphosphate + H+ (3.6.1.19)

i11: dCTP + H2O → dCMP + diphosphate + H+ (3.6.1.12/3.6.1.19/3.6.1.65)

Relationship Links: BRENDA:EC:3.6.1.19 , BRENDA:EC:3.6.1.23 , ENZYME:EC:3.6.1.19 , ENZYME:EC:3.6.1.23 , IUBMB-ExplorEnz:EC:3.6.1.19 , IUBMB-ExplorEnz:EC:3.6.1.23


References

BERTANI63: BERTANI LE, HAEGGMARK A, REICHARD P (1963). "ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOTIDES. II. FORMATION AND INTERCONVERSION OF DEOXYURIDINE PHOSPHATES." J Biol Chem 238;3407-13. PMID: 14085395

Chern69: Chern CJ, MacDonald AB, Morris AJ (1969). "Purification and properties of a nucleoside triphosphate pyrophosphohydrolase from red cells of the rabbit." J Biol Chem 244(20);5489-95. PMID: 4310599

Giroir87: Giroir LE, Deutsch WA (1987). "Drosophila deoxyuridine triphosphatase. Purification and characterization." J Biol Chem 262(1);130-4. PMID: 3025197

GREENBERG62: GREENBERG GR, SOMERVILLE RL (1962). "Deoxyuridylate kinase activity and deoxyuridinetriphosphatase in Escherichia coli." Proc Natl Acad Sci U S A 48;247-57. PMID: 13901467

Grindey71: Grindey GR, Nichol CA (1971). "Mammalian deoxyuridine 5'-triphosphate pyrophosphatase." Biochim Biophys Acta 240(2);180-3. PMID: 5105331

Zhang02b: Zhang J, Inouye M (2002). "MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli." J Bacteriol 184(19);5323-9. PMID: 12218018


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, BIOCYC13A.