Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 5.3.3.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 5.3.3.8

Enzymes and Genes:
fatty acid oxidation complex, α component Inferred from experiment : fadB
FadJ component of anaerobic fatty acid oxidation complex Inferred by computational analysis Inferred from experiment : fadJ

In Pathway: fatty acid β-oxidation I

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Instance reaction:
3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA (5.3.3.8)

Enzyme Commission Primary Name: dodecenoyl-CoA isomerase

Enzyme Commission Synonyms: δ3-cis2-trans-enoyl-CoA isomerase, acetylene-allene isomerase, dodecenoyl-CoA δ-isomerase, dodecenoyl-CoA δ3-cis2-trans-isomerase

Summary:
A reaction in β-oxidation of fatty acids, required to feed unsaturated fatty acids into the main pathway.

Enzyme Commission Summary:
Also catalyses the interconversion of 3-acetylenic fatty acyl thioesters and (+)-2,3-dienoyl fatty acyl thioesters, with fatty acid chain lengths C6 to C12.

Citations: [Stoffel78, Stoffel64, Miesowicz79]

Gene-Reaction Schematic: ?

Instance reaction of [a cis-3-enoyl-CoA ↔ a trans-2-enoyl-CoA] (5.3.3.8):
i1: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA (5.3.3.8)

Instance reaction of [a (3S)-3-hydroxyacyl-CoA + NAD+ ↔ a 3-oxoacyl-CoA + NADH + H+] (1.1.1.35):
i2: 3-hydroxy-5-cis-tetradecenoyl-CoA + NAD+ = 3-keto-5-cis-tetradecenoyl-CoA + NADH + H+ (1.1.1.211)

Relationship Links: BRENDA:EC:5.3.3.8 , ENZYME:EC:5.3.3.8 , IUBMB-ExplorEnz:EC:5.3.3.8


References

Miesowicz79: Miesowicz FM, Bloch K (1979). "Purification of hog liver isomerase. Mechanism of isomerization of 3-alkenyl and 3-alkynyl thioesters." J Biol Chem 254(13);5868-77. PMID: 376522

Stoffel64: Stoffel W, Ditzer R, Caesar H (1964). "[The metabolism of unsaturated fatty acid. 3. On the beta-oxidation of mono- and polyene-fatty acids. The mechanism of the enzymatic reaction on delta-3-cis-enoyl-CoA compounds]." Hoppe Seylers Z Physiol Chem 339(1);167-81. PMID: 5830064

Stoffel78: Stoffel W, Grol M (1978). "Purification and properties of 3-cis-2-trans-enoyl-CoA isomerase (dodecenoyl-CoA delta-isomerase) from rat liver mitochondria." Hoppe Seylers Z Physiol Chem 359(12);1777-82. PMID: 738702


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC14B.