|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
In Pathway: fatty acid β-oxidation I
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA (22.214.171.124)
Enzyme Commission Primary Name: dodecenoyl-CoA isomerase
Enzyme Commission Synonyms: δ3-cis-δ2-trans-enoyl-CoA isomerase, acetylene-allene isomerase, dodecenoyl-CoA δ-isomerase, dodecenoyl-CoA δ3-cis-δ2-trans-isomerase
A reaction in β-oxidation of fatty acids, required to feed unsaturated fatty acids into the main pathway.
Enzyme Commission Summary:
Also catalyses the interconversion of 3-acetylenic fatty acyl thioesters and (+)-2,3-dienoyl fatty acyl thioesters, with fatty acid chain lengths C6 to C12.
Instance reaction of [a cis-3-enoyl-CoA ↔ a trans-2-enoyl-CoA] (126.96.36.199):
i1: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA (188.8.131.52)
Instance reaction of [a (3S)-3-hydroxyacyl-CoA + NAD+ ↔ a 3-oxoacyl-CoA + NADH + H+] (184.108.40.206):
i2: 3-hydroxy-5-cis-tetradecenoyl-CoA + NAD+ = 3-keto-5-cis-tetradecenoyl-CoA + NADH + H+ (220.127.116.11)
Stoffel64: Stoffel W, Ditzer R, Caesar H (1964). "[The metabolism of unsaturated fatty acid. 3. On the beta-oxidation of mono- and polyene-fatty acids. The mechanism of the enzymatic reaction on delta-3-cis-enoyl-CoA compounds]." Hoppe Seylers Z Physiol Chem 339(1);167-81. PMID: 5830064
Stoffel78: Stoffel W, Grol M (1978). "Purification and properties of 3-cis-2-trans-enoyl-CoA isomerase (dodecenoyl-CoA delta-isomerase) from rat liver mitochondria." Hoppe Seylers Z Physiol Chem 359(12);1777-82. PMID: 738702
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