|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
In Pathway: fatty acid β-oxidation I
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
(S)-3-hydroxy-(9Z)-octadecenoyl-CoA ← (2E,9Z)-octadecenoyl-CoA + H2O (184.108.40.206)
(S)-3-hydroxy-(7Z)-tetradecenoyl-CoA ← (2E,7Z)-tetradecenoyl-CoA + H2O (220.127.116.11)
(S)-3-hydroxy-(5Z)-dodecenoyl-CoA ← (2E,5Z)-dodecenoyl-CoA + H2O (18.104.22.168)
Enzyme Commission Primary Name: enoyl-CoA hydratase
Enzyme Commission Synonyms: enoyl hydrase, unsaturated acyl-CoA hydratase, β-hydroxyacyl-CoA dehydrase, β-hydroxyacid dehydrase, hydratase, enoyl coenzyme A, acyl coenzyme A hydrase, crotonase, crotonyl hydrase, 2-octenoyl coenzyme A hydrase, enoyl coenzyme A hydratase, 2-enoyl-CoA hydratase, short-chain enoyl-CoA hydratase, ECH, trans-2-enoyl-CoA hydratase, enoyl coenzyme A hydrase (D), enoyl coenzyme A hydrase (L), short chain enoyl coenzyme A hydratase, D-3-hydroxyacyl-CoA dehydratase, enol-CoA hydratase
A reaction in the β-oxidation of fatty acids.
Enzyme Commission Summary:
Acts in the reverse direction. With cis-compounds, yields (3R)-3-hydroxyacyl-CoA. cf. EC 22.214.171.124, long-chain-enoyl-CoA hydratase.
Moskowitz69: Moskowitz GJ, Merrick JM (1969). "Metabolism of poly-beta-hydroxybutyrate. II. Enzymatic synthesis of D-(-)-beta hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum." Biochemistry 8(7);2748-55. PMID: 5808333
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