Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
twitter

Escherichia coli K-12 substr. MG1655 Reaction: 4.2.1.17


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 4.2.1.17

Enzymes and Genes:
fatty acid oxidation complex, α componentInferred from experiment: fadB
FadJ component of anaerobic fatty acid oxidation complexInferred by computational analysisInferred from experiment: fadJ

In Pathway: fatty acid β-oxidation I

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: enoyl-CoA hydratase

Enzyme Commission Synonyms: enoyl hydrase, unsaturated acyl-CoA hydratase, β-hydroxyacyl-CoA dehydrase, β-hydroxyacid dehydrase, hydratase, enoyl coenzyme A, acyl coenzyme A hydrase, crotonase, crotonyl hydrase, 2-octenoyl coenzyme A hydrase, enoyl coenzyme A hydratase, 2-enoyl-CoA hydratase, short-chain enoyl-CoA hydratase, ECH, trans-2-enoyl-CoA hydratase, enoyl coenzyme A hydrase (D), enoyl coenzyme A hydrase (L), short chain enoyl coenzyme A hydratase, D-3-hydroxyacyl-CoA dehydratase, enol-CoA hydratase

Summary:
A reaction in the β-oxidation of fatty acids.

Enzyme Commission Summary:
Acts in the reverse direction. With cis-compounds, yields (3R)-3-hydroxyacyl-CoA. cf. EC 4.2.1.74 long-chain-enoyl-CoA hydratase.

Citations: [Moskowitz69, Stern57 ]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [a cis-3-enoyl-CoA ↔ a trans-2-enoyl-CoA] (5.3.3.8):
i1: 3-cis-dodecenoyl-CoA = trans-dodec-2-enoyl-CoA (5.3.3.8)

Instance reaction of [a (3S)-3-hydroxyacyl-CoA + NAD+ → a 3-oxoacyl-CoA + NADH + H+] (1.1.1.35):
i2: 3-hydroxy-5-cis-tetradecenoyl-CoA + NAD+ = 3-keto-5-cis-tetradecenoyl-CoA + NADH + H+ (1.1.1.211)

Relationship Links: BRENDA:EC:4.2.1.17, ENZYME:EC:4.2.1.17, IUBMB-ExplorEnz:EC:4.2.1.17


References

Moskowitz69: Moskowitz GJ, Merrick JM (1969). "Metabolism of poly-beta-hydroxybutyrate. II. Enzymatic synthesis of D-(-)-beta hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum." Biochemistry 8(7);2748-55. PMID: 5808333

Stern57: Stern JR (1957). "Thioltranscrotonylase and beta-hydroxybutyryl COA racemase activities of crystalline crotonase." Biochim Biophys Acta 26(3);641-3. PMID: 13499425


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Feb 10, 2016, biocyc11.