Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 3.1.3.11

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.3.11

Enzymes and Genes:
alkaline phosphatase Inferred from experiment : phoA
fructose-1,6-bisphosphatase Inferred from experiment : yggF
fructose 1,6-bisphosphatase Inferred from experiment : ybhA
fructose 1,6-bisphosphatase II Inferred from experiment : glpX
fructose-1,6-bisphosphatase I Inferred from experiment : fbp

In Pathway: gluconeogenesis I , glycolysis II (from fructose-6P) , glycolysis I (from glucose-6P)

Reaction Locations: periplasmic space (sensu Gram-negative Bacteria), cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: fructose-bisphosphatase

Enzyme Commission Synonyms: hexose diphosphatase, FBPase, fructose 1,6-diphosphatase, fructose 1,6-diphosphate phosphatase, D-fructose 1,6-diphosphatase, fructose 1,6-bisphosphatase, fructose diphosphatase, fructose diphosphate phosphatase, fructose bisphosphate phosphatase, fructose 1,6-bisphosphate 1-phosphatase, fructose 1,6-bisphosphate phosphatase, hexose bisphosphatase, D-fructose-1,6-bisphosphate phosphatase

Summary:
This is an essential reaction of the gluconeogenic pathway and plays an important role in its regulation.

Enzyme Commission Summary:
The animal enzyme also acts on sedoheptulose 1,7-bisphosphate.

Citations: [MCGILVERY56, Pontremoli65]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.1.3.11 , ENZYME:EC:3.1.3.11 , IUBMB-ExplorEnz:EC:3.1.3.11


References

MCGILVERY56: MCGILVERY RW, MOKRASCH LC (1956). "Purification and properties of fructose-1, 6-diphosphatase." J Biol Chem 221(2);909-17. PMID: 13357486

Pontremoli65: Pontremoli S, Traniello S, Luppis B, Wood WA (1965). "Fructose diphosphatase from rabbit liver. I. Purification and properties." J Biol Chem 240(9);3459-63. PMID: 4284291


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, BIOCYC13A.