Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
alkaline phosphataseInferred from experiment: phoA
fructose-1,6-bisphosphataseInferred from experiment: yggF
fructose 1,6-bisphosphataseInferred from experiment: ybhA
fructose 1,6-bisphosphatase IIInferred from experiment: glpX
fructose-1,6-bisphosphatase IInferred from experiment: fbp

In Pathway: gluconeogenesis I, glycolysis II (from fructose 6-phosphate), glycolysis I (from glucose 6-phosphate)

Reaction Locations: periplasm (sensu Gram-negative Bacteria), cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: fructose-bisphosphatase

Enzyme Commission Synonyms: hexose diphosphatase, FBPase, fructose 1,6-diphosphatase, fructose 1,6-diphosphate phosphatase, D-fructose 1,6-diphosphatase, fructose 1,6-bisphosphatase, fructose diphosphatase, fructose diphosphate phosphatase, fructose bisphosphate phosphatase, fructose 1,6-bisphosphate 1-phosphatase, fructose 1,6-bisphosphate phosphatase, hexose bisphosphatase, D-fructose-1,6-bisphosphate phosphatase

This is an essential reaction of the gluconeogenic pathway and plays an important role in its regulation.

Enzyme Commission Summary:
The animal enzyme also acts on sedoheptulose 1,7-bisphosphate.

Citations: [MCGILVERY56, Pontremoli65]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


MCGILVERY56: MCGILVERY RW, MOKRASCH LC (1956). "Purification and properties of fructose-1, 6-diphosphatase." J Biol Chem 221(2);909-17. PMID: 13357486

Pontremoli65: Pontremoli S, Traniello S, Luppis B, Wood WA (1965). "Fructose diphosphatase from rabbit liver. I. Purification and properties." J Biol Chem 240(9);3459-63. PMID: 4284291

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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