|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Composite Reactions → Electron-Transfer-Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.
Reaction Locations: inner membrane (sensu Gram-negative Bacteria)
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: formate dehydrogenase-N
Enzyme Commission Synonyms: Fdh-N, FdnGHI, nitrate-inducible formate dehydrogenase, formate dehydrogenase N, FDH-N, nitrate inducible Fdn, nitrate inducible formate dehydrogenase
This is the first step in the metabolism of formate under anaerobic conditions.
Enzyme Commission Summary:
The enzyme contains molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters and two heme b groups. Formate dehydrogenase-N oxidizes formate in the periplasm, transferring electrons via the menaquinone pool in the cytoplasmic membrane to a dissimilatory nitrate reductase (EC 126.96.36.199), which transfers electrons to nitrate in the cytoplasm. The system generates proton motive force under anaerobic conditions [Jormakka02a].
Jormakka02a: Jormakka M, Tornroth S, Abramson J, Byrne B, Iwata S (2002). "Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli." Acta Crystallogr D Biol Crystallogr 58(Pt 1);160-2. PMID: 11752799
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