Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 3.6.1.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.1.1

Enzymes and Genes:
alkaline phosphatase Inferred from experiment : phoA
inorganic pyrophosphatase Inferred from experiment : ppa

Reaction Locations: periplasmic space (sensu Gram-negative Bacteria), cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: inorganic diphosphatase

Enzyme Commission Synonyms: Diphosphate phosphohydrolase, Pyrophosphate phosphohydrolase, Inorganic diphosphatase

Summary:
This reaction is part of central intermediary metabolism. It provides a thermodynamic pull for biosynthetic reactions that produce pyrophosphate.

Enzyme Commission Summary:
Specificity varies with the source and with the activating metal ion. The enzyme from some sources may be identical with EC 3.1.3.1 (alkaline phosphatase) or EC 3.1.3.9 (glucose-6-phosphatase). A form of this enzyme with a molecular mass of about 90 kDa is found in tonoplasts of plants and fungi, where it imports protons from the cytosol into the vacuolar lumen.

Citations: [Bailey44, KUNITZ52, RAFTER60]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.6.1.1 , ENZYME:EC:3.6.1.1 , IUBMB-ExplorEnz:EC:3.6.1.1


References

Bailey44: Bailey K, Webb EC (1944). "Purification and properties of yeast pyrophosphatase." Biochem J 38(5);394-8. PMID: 16747821

KUNITZ52: KUNITZ M (1952). "Crystalline inorganic pyrophosphatase isolated from baker's yeast." J Gen Physiol 35(3);423-50. PMID: 14898026

RAFTER60: RAFTER GW (1960). "Pyrophosphate metabolism in liver mitochondria." J Biol Chem 235;2475-7. PMID: 14435825


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC14A.