Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
alkaline phosphatase Inferred from experiment : phoA
inorganic pyrophosphatase Inferred from experiment : ppa

Reaction Locations: periplasmic space (sensu Gram-negative Bacteria), cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: inorganic diphosphatase

Enzyme Commission Synonyms: Diphosphate phosphohydrolase, Pyrophosphate phosphohydrolase, Inorganic diphosphatase

This reaction is part of central intermediary metabolism. It provides a thermodynamic pull for biosynthetic reactions that produce pyrophosphate.

Enzyme Commission Summary:
Specificity varies with the source and with the activating metal ion. The enzyme from some sources may be identical with EC (alkaline phosphatase) or EC (glucose-6-phosphatase). A form of this enzyme with a molecular mass of about 90 kDa is found in tonoplasts of plants and fungi, where it imports protons from the cytosol into the vacuolar lumen.

Citations: [Bailey44, KUNITZ52, RAFTER60]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Bailey44: Bailey K, Webb EC (1944). "Purification and properties of yeast pyrophosphatase." Biochem J 38(5);394-8. PMID: 16747821

KUNITZ52: KUNITZ M (1952). "Crystalline inorganic pyrophosphatase isolated from baker's yeast." J Gen Physiol 35(3);423-50. PMID: 14898026

RAFTER60: RAFTER GW (1960). "Pyrophosphate metabolism in liver mitochondria." J Biol Chem 235;2475-7. PMID: 14435825

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Thu May 7, 2015, biocyc14.