Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
alkaline phosphataseInferred from experiment: phoA
inorganic pyrophosphataseInferred from experiment: ppa

Reaction Locations: periplasm (sensu Gram-negative Bacteria), cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: inorganic diphosphatase

Enzyme Commission Synonyms: Diphosphate phosphohydrolase, Pyrophosphate phosphohydrolase, Inorganic diphosphatase

This reaction is part of central intermediary metabolism. It provides a thermodynamic pull for biosynthetic reactions that produce pyrophosphate.

Enzyme Commission Summary:
Specificity varies with the source and with the activating metal ion. The enzyme from some sources may be identical with EC (alkaline phosphatase) or EC (glucose-6-phosphatase). A form of this enzyme with a molecular mass of about 90 kDa is found in tonoplasts of plants and fungi, where it imports protons from the cytosol into the vacuolar lumen.

Citations: [Bailey44, KUNITZ52, RAFTER60]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Bailey44: Bailey K, Webb EC (1944). "Purification and properties of yeast pyrophosphatase." Biochem J 38(5);394-8. PMID: 16747821

KUNITZ52: KUNITZ M (1952). "Crystalline inorganic pyrophosphatase isolated from baker's yeast." J Gen Physiol 35(3);423-50. PMID: 14898026

RAFTER60: RAFTER GW (1960). "Pyrophosphate metabolism in liver mitochondria." J Biol Chem 235;2475-7. PMID: 14435825

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon Nov 30, 2015, biocyc11.