Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateMacromolecule ReactionsPolynucleotide-ReactionsRNA-ReactionstRNA-ReactionstRNA-Charging-Reactions

EC Number:

Enzymes and Genes:
lysyl-tRNA synthetase, constitutiveInferred from experiment: lysS
lysyl-tRNA synthetaseInferred from experiment: lysU

In Pathway: tRNA charging

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: lysine—tRNA ligase

Enzyme Commission Synonyms: lysyl-tRNA synthetase, lysyl-transfer ribonucleate synthetase, lysyl-transfer RNA synthetase, L-lysine-transfer RNA ligase, lysine-tRNA synthetase, lysine translase

Citations: [Allen60, Chlumecka69, Lagerkvist72, Stern65]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [an acyl-carrier protein + coenzyme A → adenosine 3',5'-bisphosphate + a holo-[acyl-carrier protein] + H+] (
i1: [EntB aryl-carrier protein] + coenzyme A → a holo-[EntB isochorismatase/aryl-carrier protein] + adenosine 3',5'-bisphosphate + H+ (

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Allen60: Allen EH, Glassman E, Schweet RS (1960). "Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes." J Biol Chem 235;1061-7. PMID: 13792726

Chlumecka69: Chlumecka V, Von Tigerstrom M, D'Obrenan P, Smith CJ (1969). "Purification and properties of lysyl transfer ribonucleic acid synthetase from bakers' yeast." J Biol Chem 244(20);5481-8. PMID: 4310598

Lagerkvist72: Lagerkvist U, Rymo L, Lindqvist O, Andersson E (1972). "Some properties of crystals of lysine transfer ribonucleic acid ligase from yeast." J Biol Chem 247(12);3897-9. PMID: 4555953

Stern65: Stern R, Mehler AH (1965). "Lysyl-sRNA synthetase from Escherichia coli." Biochem Z 342(4);400-9. PMID: 4284804

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.5 on Wed Nov 25, 2015, BIOCYC14A.