Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions tRNA-Reactions tRNA-Charging-Reactions

EC Number:

Enzymes and Genes:
lysyl-tRNA synthetase, constitutive Inferred from experiment : lysS
lysyl-tRNA synthetase Inferred from experiment : lysU

In Pathway: tRNA charging

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: lysine—tRNA ligase

Enzyme Commission Synonyms: lysyl-tRNA synθse, lysyl-transfer ribonucleate synθse, lysyl-transfer RNA synθse, L-lysine-transfer RNA ligase, lysine-tRNA synθse, lysine translase

Citations: [Allen60, Chlumecka69, Lagerkvist72, Stern65]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [an acyl-carrier protein + coenzyme A → adenosine 3',5'-bisphosphate + a holo-[acyl-carrier protein] + H+] (
i1: [EntB aryl-carrier protein] + coenzyme A → a holo-[EntB isochorismatase/aryl-carrier protein] + adenosine 3',5'-bisphosphate + H+ (

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Allen60: Allen EH, Glassman E, Schweet RS (1960). "Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes." J Biol Chem 235;1061-7. PMID: 13792726

Chlumecka69: Chlumecka V, Von Tigerstrom M, D'Obrenan P, Smith CJ (1969). "Purification and properties of lysyl transfer ribonucleic acid synthetase from bakers' yeast." J Biol Chem 244(20);5481-8. PMID: 4310598

Lagerkvist72: Lagerkvist U, Rymo L, Lindqvist O, Andersson E (1972). "Some properties of crystals of lysine transfer ribonucleic acid ligase from yeast." J Biol Chem 247(12);3897-9. PMID: 4555953

Stern65: Stern R, Mehler AH (1965). "Lysyl-sRNA synthetase from Escherichia coli." Biochem Z 342(4);400-9. PMID: 4284804

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Mon Oct 5, 2015, BIOCYC14A.