Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase Inferred from experiment : folD

In Pathway: N10-formyl-tetrahydrofolate biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: methylenetetrahydrofolate dehydrogenase (NADP+)

Enzyme Commission Synonyms: N5,N10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate:NADP oxidoreductase, 5,10-methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase (NADP)

Enzyme Commission Summary:
This reaction is involved in folic acid synthesis and is necessary for the biosynthesis of purines, thymydylate, methionine, histidine, pantothenate and formyl tRNA-MET.

Citations: [Yeh65, RAMASASTRI62, OSBORN57, HATEFI57]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


HATEFI57: HATEFI Y, OSBORN MJ, KAY LD, HUENNEKENS FM (1957). "Hydroxymethyl tetrahydrofolic dehydrogenase." J Biol Chem 227(2);637-47. PMID: 13462986

OSBORN57: OSBORN MJ, HUENNEKENS FM (1957). "Participation of anhydroleucovorin in the hydroxymethyl tetrahydrofolic dehydrogenase system." Biochim Biophys Acta 26(3);646-7. PMID: 13499428

RAMASASTRI62: RAMASASTRI BV, BLAKLEY RL (1962). "5,10-Methylenetetrahydrofolic dehydrogenase from bakers' yeast. I. Partial purification and some properties." J Biol Chem 237;1982-8. PMID: 14490085

Yeh65: Yeh YC, Greenberg DM (1965). "Purification and properties of N5, N10-Methylenetetra-hydrofolate dehydrogenase of calf thymus." Biochim Biophys Acta 105(2);279-91. PMID: 4379024

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Sat Oct 10, 2015, biocyc13.