Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 6.3.5.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 6.3.5.1

Enzymes and Genes:
NAD synthetase, NH3-dependent Inferred from experiment : nadE

In Pathway: NAD biosynthesis I (from aspartate) , NAD salvage pathway I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: NAD+ synthase (glutamine-hydrolysing)

Enzyme Commission Synonyms: NAD synθse (glutamine-hydrolysing), nicotinamide adenine dinucleotide synθse (glutamine), desamidonicotinamide adenine dinucleotide amidotransferase, DPN synθse

Summary:
A reaction in the biosynthesis of NAD. Ammonia can also serve as a nitrogen donor.

Enzyme Commission Summary:
NH3 can act instead of glutamine (cf. EC 6.3.1.5 NAD+ synthase).

Citations: [IMSANDE61, Imsande61]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:6.3.5.1 , ENZYME:EC:6.3.5.1 , IUBMB-ExplorEnz:EC:6.3.5.1


References

Imsande61: Imsande J (1961). "Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli." J Biol Chem 1961;236(5):1494-1497. PMID: 13717628

IMSANDE61: IMSANDE J, HANDLER P (1961). "Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophos-phorylase." J Biol Chem 236;525-30. PMID: 13717627


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc13.