Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
NAD synthetase, NH3-dependent : nadE

In Pathway: NAD biosynthesis I (from aspartate) , NAD salvage pathway I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: NAD+ synthase (glutamine-hydrolysing)

Enzyme Commission Synonyms: NAD synθse (glutamine-hydrolysing), nicotinamide adenine dinucleotide synθse (glutamine), desamidonicotinamide adenine dinucleotide amidotransferase, DPN synθse

A reaction in the biosynthesis of NAD. Ammonia can also serve as a nitrogen donor.

Enzyme Commission Summary:
NH3 can act instead of glutamine (cf. EC NAD+ synthase).

Citations: [IMSANDE61, Imsande61]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Imsande61: Imsande J (1961). "Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli." J Biol Chem 1961;236(5):1494-1497. PMID: 13717628

IMSANDE61: IMSANDE J, HANDLER P (1961). "Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophos-phorylase." J Biol Chem 236;525-30. PMID: 13717627

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Sat Jul 4, 2015, biocyc11.