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Escherichia coli K-12 substr. MG1655 Reaction: 6.3.5.1


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 6.3.5.1

Enzymes and Genes:
NAD synthetase, NH3-dependent: nadE

In Pathway: NAD biosynthesis I (from aspartate), NAD salvage pathway I

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: NAD+ synthase (glutamine-hydrolysing)

Enzyme Commission Synonyms: NAD synthetase (glutamine-hydrolysing), nicotinamide adenine dinucleotide synthetase (glutamine), desamidonicotinamide adenine dinucleotide amidotransferase, DPN synthetase

Summary:
A reaction in the biosynthesis of NAD. Ammonia can also serve as a nitrogen donor.

Enzyme Commission Summary:
NH3 can act instead of glutamine (cf. EC 6.3.1.5 NAD+ synthase).

Citations: [Imsande61a, Imsande61]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:6.3.5.1, ENZYME:EC:6.3.5.1, IUBMB-ExplorEnz:EC:6.3.5.1


References

Imsande61: Imsande J (1961). "Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli." J Biol Chem 1961;236(5):1494-1497. PMID: 13717628

Imsande61a: Imsande J, Handler P (1961). "Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophos-phorylase." J Biol Chem 236;525-30. PMID: 13717627


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Feb 11, 2016, biocyc14.