|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
In Pathway: L-arginine biosynthesis I (via L-ornithine)
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: ornithine carbamoyltransferase
Enzyme Commission Synonyms: citrulline phosphorylase, ornithine transcarbamylase, OTC, carbamylphosphate-ornithine transcarbamylase, L-ornithine carbamoyltransferase, L-ornithine carbamyltransferase, L-ornithine transcarbamylase, ornithine carbamyltransferase
This is the sixth step in arginine biosynthesis. It is also part of the urea cycle.
Enzyme Commission Summary:
The plant enzyme also catalyses the reactions of EC 18.104.22.168 putrescine carbamoyltransferase, EC 22.214.171.124 carbamate kinase and EC 126.96.36.199 agmatine deiminase, thus acting as putrescine synthase, converting agmatine [(4-aminobutyl)guanidine] and ornithine into putrescine and citrulline, respectively.
Marshall72a: Marshall M, Cohen PP (1972). "Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. II. Multiple binding sites for carbamyl-P and L-norvaline, correlation with steady state kinetics." J Biol Chem 247(6);1654-68. PMID: 4622304
Marshall72b: Marshall M, Cohen PP (1972). "Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. 3. Effects of chemical modifications of specific residues on ligand binding and enzymatic activity." J Biol Chem 247(6);1669-82. PMID: 4622305
©2015 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493