Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
phenylacetate-CoA ligase Inferred by computational analysis : paaK

In Pathway: phenylacetate degradation I (aerobic)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phenylacetate—CoA ligase

Enzyme Commission Synonyms: phenacyl coenzyme A synθse, phenylacetyl-CoA ligase, PA-CoA ligase, phenylacetyl-CoA ligase (AMP-forming)

Enzyme Commission Summary:
Also acts, more slowly, on acetate, propanoate and butanoate, but not on hydroxy derivatives of phenylacetate and related compounds.

Citations: [MartinezBlanco90, Ferrandez98, MOLDAVE57, Vessey99, Vessey03]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Ferrandez98: Ferrandez A, Minambres B, Garcia B, Olivera ER, Luengo JM, Garcia JL, Diaz E (1998). "Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway." J Biol Chem 1998;273(40);25974-86. PMID: 9748275

MartinezBlanco90: Martinez-Blanco H, Reglero A, Rodriguez-Aparicio LB, Luengo JM (1990). "Purification and biochemical characterization of phenylacetyl-CoA ligase from Pseudomonas putida. A specific enzyme for the catabolism of phenylacetic acid." J Biol Chem 265(12);7084-90. PMID: 2324116

MOLDAVE57: MOLDAVE K, MEISTER A (1957). "Synthesis of phenylacetylglutamine by human tissue." J Biol Chem 229(1);463-76. PMID: 13491597

Vessey03: Vessey DA, Lau E, Kelley M, Warren RS (2003). "Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria." J Biochem Mol Toxicol 17(1);1-6. PMID: 12616642

Vessey99: Vessey DA, Kelley M, Warren RS (1999). "Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids." Biochim Biophys Acta 1428(2-3);455-62. PMID: 10434065

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Tue Mar 31, 2015, biocyc13.