Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 6.2.1.30

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 6.2.1.30

Enzymes and Genes:
phenylacetate-CoA ligase Inferred by computational analysis : paaK

In Pathway: phenylacetate degradation I (aerobic)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phenylacetate—CoA ligase

Enzyme Commission Synonyms: phenacyl coenzyme A synθse, phenylacetyl-CoA ligase, PA-CoA ligase, phenylacetyl-CoA ligase (AMP-forming)

Enzyme Commission Summary:
Also acts, more slowly, on acetate, propanoate and butanoate, but not on hydroxy derivatives of phenylacetate and related compounds.

Citations: [MartinezBlanco90, Ferrandez98, MOLDAVE57, Vessey99, Vessey03]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:6.2.1.30 , ENZYME:EC:6.2.1.30 , IUBMB-ExplorEnz:EC:6.2.1.30


References

Ferrandez98: Ferrandez A, Minambres B, Garcia B, Olivera ER, Luengo JM, Garcia JL, Diaz E (1998). "Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway." J Biol Chem 1998;273(40);25974-86. PMID: 9748275

MartinezBlanco90: Martinez-Blanco H, Reglero A, Rodriguez-Aparicio LB, Luengo JM (1990). "Purification and biochemical characterization of phenylacetyl-CoA ligase from Pseudomonas putida. A specific enzyme for the catabolism of phenylacetic acid." J Biol Chem 265(12);7084-90. PMID: 2324116

MOLDAVE57: MOLDAVE K, MEISTER A (1957). "Synthesis of phenylacetylglutamine by human tissue." J Biol Chem 229(1);463-76. PMID: 13491597

Vessey03: Vessey DA, Lau E, Kelley M, Warren RS (2003). "Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria." J Biochem Mol Toxicol 17(1);1-6. PMID: 12616642

Vessey99: Vessey DA, Kelley M, Warren RS (1999). "Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids." Biochim Biophys Acta 1428(2-3);455-62. PMID: 10434065


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC14B.