Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
phosphate acetyltransferaseInferred from experiment: eutD
phosphate acetyltransferaseInferred from experiment: pta

In Pathway: acetate formation from acetyl-CoA I, mixed acid fermentation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphate acetyltransferase

Enzyme Commission Synonyms: phosphotransacetylase, phosphoacylase, PTA

The first reaction in the conversion of acetyl-CoA to acetate.

Enzyme Commission Summary:
Also acts with other short-chain acyl-CoAs.

Citations: [STADTMAN52, Bergmeyer63]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Bergmeyer63: Bergmeyer, H.U., Holz, G., Klotzsch, H., Lang, G. (1963). "[Phosphotransacetylase from Clostridium kluyveri. Culture of the bacterium, isolation, crystallization and properties of the enzyme.]." Biochem Z 338;114-21. PMID: 14087284

STADTMAN52: STADTMAN ER (1952). "The purification and properties of phosphotransacetylase." J Biol Chem 196(2);527-34. PMID: 12980995

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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