Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 4.2.1.51

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.2.1.51

Enzymes and Genes:
chorismate mutase / prephenate dehydratase Inferred from experiment : pheA

In Pathway: phenylalanine biosynthesis I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: prephenate dehydratase

Enzyme Commission Synonyms: prephenate hydro-lyase (decarboxylating)

Summary:
This is the second reaction after chorismate in the biosynthesis of phenylalanine. It differs from the corresponding step in the biosynthesis of tyrosine in that it is a dehydratase, not a dehydrogenase.

Enzyme Commission Summary:
This enzyme in the enteric bacteria also possesses chorismate mutase (EC 5.4.99.5) activity, and converts chorismate into prephenate.

Citations: [COTTON65, CERUTTI65]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:4.2.1.51 , ENZYME:EC:4.2.1.51 , IUBMB-ExplorEnz:EC:4.2.1.51


References

CERUTTI65: CERUTTI P, GUROFF G (1965). "ENZYMATIC FORMATION OF PHENYLPYRUVIC ACID IN PSEUDOMONAS SP. (ATCC 11299A) AND ITS REGULATION." J Biol Chem 240;3034-8. PMID: 14342329

COTTON65: COTTON RG, GIBSON F (1965). "THE BIOSYNTHESIS OF PHENYLALANINE AND TYROSINE; ENZYMES CONVERTING CHORISMIC ACID INTO PREPHENIC ACID AND THEIR RELATIONSHIPS TO PREPHENATE DEHYDRATASE AND PREPHENATE DEHYDROGENASE." Biochim Biophys Acta 100;76-88. PMID: 14323651


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC14A.