|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
In Pathway: L-phenylalanine biosynthesis I
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: prephenate dehydratase
Enzyme Commission Synonyms: prephenate hydro-lyase (decarboxylating)
This is the second reaction after chorismate in the biosynthesis of phenylalanine. It differs from the corresponding step in the biosynthesis of tyrosine in that it is a dehydratase, not a dehydrogenase.
Enzyme Commission Summary:
This enzyme in the enteric bacteria also possesses chorismate mutase (EC 18.104.22.168) activity, and converts chorismate into prephenate.
Cotton65: Cotton RG, Gibson F (1965). "The biosynthesis of phenylalanine and tyrosine; enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenase." Biochim Biophys Acta 100;76-88. PMID: 14323651
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