Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 2.7.2.15

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.2.15

Enzymes and Genes:
acetate kinase Inferred from experiment : ackA
propionate kinase Inferred from experiment : tdcD

In Pathway: threonine degradation I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: propionate kinase

Enzyme Commission Synonyms: PduW, TdcD, propionate/acetate kinase

Summary:
This is the final reaction in the anaerobic L-threonine degradation pathway.

Requires Mg2+. Both propanoate and acetate can act as a substrate. Involved in the anaerobic degradation of L-threonine in bacteria [Hesslinger98]. Both this enzyme and EC 2.7.2.1, acetate kinase, play important roles in the production of propanoate.

Requires Mg2+. Both propanoate and acetate can act as a substrate. Involved in the anaerobic degradation of L-threonine in bacteria [Hesslinger98]. Both this enzyme and EC 2.7.2.1, acetate kinase, play important roles in the production of propanoate.

Enzyme Commission Summary:
Requires Mg2+. Both propanoate and acetate can act as a substrate. Involved in the anaerobic degradation of L-threonine in bacteria [Hesslinger98]. Both this enzyme and EC 2.7.2.1, acetate kinase, play important roles in the production of propanoate [Hesslinger98].

Citations: [Palacios03, Wei99, IngramSmith05, Simanshu05, Simanshu05a]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.7.2.15 , ENZYME:EC:2.7.2.15 , IUBMB-ExplorEnz:EC:2.7.2.15


References

Hesslinger98: Hesslinger C, Fairhurst SA, Sawers G (1998). "Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate." Mol Microbiol 1998;27(2);477-92. PMID: 9484901

IngramSmith05: Ingram-Smith C, Gorrell A, Lawrence SH, Iyer P, Smith K, Ferry JG (2005). "Characterization of the acetate binding pocket in the Methanosarcina thermophila acetate kinase." J Bacteriol 187(7);2386-94. PMID: 15774882

Palacios03: Palacios S, Starai VJ, Escalante-Semerena JC (2003). "Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol." J Bacteriol 185(9);2802-10. PMID: 12700259

Simanshu05: Simanshu DK, Murthy MR (2005). "Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of propionate kinase (TdcD) from Salmonella typhimurium." Acta Crystallogr Sect F Struct Biol Cryst Commun 61(Pt 1);52-5. PMID: 16508089

Simanshu05a: Simanshu DK, Savithri HS, Murthy MR (2005). "Crystal structures of ADP and AMPPNP-bound propionate kinase (TdcD) from Salmonella typhimurium: comparison with members of acetate and sugar kinase/heat shock cognate 70/actin superfamily." J Mol Biol 352(4);876-92. PMID: 16139298

Wei99: Wei Y, Miller CG (1999). "Characterization of a group of anaerobically induced, fnr-dependent genes of Salmonella typhimurium." J Bacteriol 181(19);6092-7. PMID: 10498722


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC14B.