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Escherichia coli K-12 substr. MG1655 Reaction: 1.2.1.-


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsComposite Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.2.1.-

Enzymes and Genes:
pyruvate dehydrogenaseInferred from experiment: aceE, aceF, lpd

In Pathway: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1.2.1 -- With NAD(+) or NADP(+) as acceptor

Sub-reactions:
pyruvate + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + H+ → a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + CO2,
acetyl-CoA + a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine ← a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + coenzyme A,
a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + NAD+ → a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + NADH + H+

Summary:
This complex reaction bridges between the pathway of glycolysis and the TCA cycle. Details of the component reactions are found by querying the pyruvate dehydrogenase multienzyme complex.

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [a [lipoyl-carrier protein] N6-dihydrolipoyl-L-lysine + NAD+ = a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + NADH + H+] (1.8.1.4):
i1: a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine + NAD+ ↔ a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + NADH + H+ (1.8.1.4)

i2: a [2-oxoglutarate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + NAD+ → a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + NADH + H+ (1.8.1.4)

i3: a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + NAD+ → a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + NADH + H+ (1.8.1.4)


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun May 1, 2016, biocyc11.