Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 2.6.1.88

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.6.1.88

Enzymes and Genes:
methionine-oxo-acid transaminase, PLP-dependent Inferred from experiment : ybdL

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: methionine transaminase

Enzyme Commission Synonyms: methionine-oxo-acid transaminase

Enzyme Commission Summary:
The enzyme is most active with L-methionine. It participates in the L-methionine salvage pathway from S-methyl-5'-thioadenosine, a by-product of polyamine biosynthesis. The enzyme from the bacterium Klebsiella pneumoniae can use several different amino acids as amino donor, with aromatic amino acids being the most effective [Heilbronn99]. The enzyme from the plant Arabidopsis thaliana is also a part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates [Schuster06].

Citations: [Dolzan04]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.6.1.88 , ENZYME:EC:2.6.1.88 , IUBMB-ExplorEnz:EC:2.6.1.88

Credits:
Created 06-Apr-2010 by Keseler I , SRI International


References

Dolzan04: Dolzan M, Johansson K, Roig-Zamboni V, Campanacci V, Tegoni M, Schneider G, Cambillau C (2004). "Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function." FEBS Lett 571(1-3);141-6. PMID: 15280032

Heilbronn99: Heilbronn J, Wilson J, Berger BJ (1999). "Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae." J Bacteriol 181(6);1739-47. PMID: 10074065

Schuster06: Schuster J, Knill T, Reichelt M, Gershenzon J, Binder S (2006). "Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis." Plant Cell 18(10);2664-79. PMID: 17056707


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC14B.