Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
ribose-5-phosphate isomerase AInferred from experiment: rpiA
allose-6-phosphate isomerase / ribose-5-phosphate isomerase BInferred from experiment: rpiB

In Pathway: pentose phosphate pathway (non-oxidative branch)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ribose-5-phosphate isomerase

Enzyme Commission Synonyms: phosphopentosisomerase, phosphoriboisomerase, ribose phosphate isomerase, 5-phosphoribose isomerase, D-ribose 5-phosphate isomerase, D-ribose-5-phosphate ketol-isomerase

Part of the pentose phosphate pathway. This is part of the non-oxidative branch of the path, leading to xylulose 5-phosphate.

Enzyme Commission Summary:
Also acts on D-ribose 5-diphosphate and D-ribose 5-triphosphate.


Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


DICKENS56: DICKENS F, WILLIAMSON DH (1956). "Pentose phosphate isomerase and epimerase from animal tissues." Biochem J 64(3);567-78. PMID: 13373810

HORECKER51: HORECKER BL, SMYRNIOTIS PZ, SEEGMILLER JE (1951). "The enzymatic conversion of 6-phosphogluconate to ribulose-5-phosphate and ribose-5-phosphate." J Biol Chem 193(1);383-96. PMID: 14907726

HURWITZ56: HURWITZ J, WEISSBACH A, HORECKER BL, SMYRNIOTIS PZ (1956). "Spinach phosphoribulokinase." J Biol Chem 218(2);769-83. PMID: 13295229

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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