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Escherichia coli K-12 substr. MG1655 Reaction: 2.1.1.187

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions

EC Number: 2.1.1.187

Enzymes and Genes:
23S rRNA m1G745 methyltransferase Inferred from experiment : rlmA

Supersedes EC number: 2.1.1.51

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 23S rRNA (guanine745-N1)-methyltransferase

Enzyme Commission Synonyms: Rlma(I), Rlma1, 23S rRNA m1G745 methyltransferase, YebH, RlmAI methyltransferase, ribosomal RNA(m1G)-methylase (ambiguous), rRNA(m1G)methylase (ambiguous), RrmA (ambiguous), 23S rRNA:m1G745 methyltransferase

Enzyme Commission Summary:
The enzyme specifically methylates guanine745 at N1 in 23S rRNA.

Citations: [Liu04b, Gustafsson98, Das04, Hansen01a, Liu02]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.1.1.187 , ENZYME:EC:2.1.1.187 , IUBMB-ExplorEnz:EC:2.1.1.187

Credits:
Created 09-Aug-2010 by Caspi R , SRI International


References

Das04: Das K, Acton T, Chiang Y, Shih L, Arnold E, Montelione GT (2004). "Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site." Proc Natl Acad Sci U S A 101(12);4041-6. PMID: 14999102

Gustafsson98: Gustafsson C, Persson BC (1998). "Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant." J Bacteriol 180(2);359-65. PMID: 9440525

Hansen01a: Hansen LH, Kirpekar F, Douthwaite S (2001). "Recognition of nucleotide G745 in 23 S ribosomal RNA by the rrmA methyltransferase." J Mol Biol 310(5);1001-10. PMID: 11501991

Liu02: Liu M, Douthwaite S (2002). "Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria." Mol Microbiol 44(1);195-204. PMID: 11967079

Liu04b: Liu M, Novotny GW, Douthwaite S (2004). "Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase." RNA 10(11);1713-20. PMID: 15388872


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC14A.