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Metabolic Modeling Tutorial
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Escherichia coli K-12 substr. MG1655 Reaction: 2.1.1.172

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions

EC Number: 2.1.1.172

Enzymes and Genes:
16S rRNA m2G1207 methyltransferase Inferred from experiment : rsmC

Supersedes EC number: 2.1.1.52

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 16S rRNA (guanine1207-N2)-methyltransferase

Enzyme Commission Synonyms: m2G1207 methyltransferase

Enzyme Commission Summary:
The enzyme reacts well with 30S subunits reconstituted from 16S RNA transcripts and 30S proteins but is almost inactive with the corresponding free RNA [Tscherne99]. The enzyme specifically methylates guanine1207 at N2 in 16S rRNA.

Citations: [Sunita07]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.1.1.172 , ENZYME:EC:2.1.1.172 , IUBMB-ExplorEnz:EC:2.1.1.172

Credits:
Created 09-Aug-2010 by Kothari A , SRI International


References

Sunita07: Sunita S, Purta E, Durawa M, Tkaczuk KL, Swaathi J, Bujnicki JM, Sivaraman J (2007). "Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC." Nucleic Acids Res 35(13);4264-74. PMID: 17576679

Tscherne99: Tscherne JS, Nurse K, Popienick P, Ofengand J (1999). "Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli." J Biol Chem 274(2);924-9. PMID: 9873033


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Wed Dec 17, 2014, BIOCYC14B.