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Escherichia coli K-12 substr. MG1655 Reaction: 2.1.1.174

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions

EC Number: 2.1.1.174

Enzymes and Genes:
23S rRNA m2G1835 methyltransferase Inferred from experiment : rlmG

Supersedes EC number: 2.1.1.52

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 23S rRNA (guanine1835-N2)-methyltransferase

Enzyme Commission Synonyms: ygjO (gene name), rlmG (gene name), ribosomal RNA large subunit methyltransferase G

Enzyme Commission Summary:
The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate [Sergiev06]. The enzyme specifically methylates guanine1835 at N2 in 23S rRNA.

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:2.1.1.174 , ENZYME:EC:2.1.1.174 , IUBMB-ExplorEnz:EC:2.1.1.174

Credits:
Created 23-Aug-2010 by Kothari A , SRI International


References

Sergiev06: Sergiev PV, Lesnyak DV, Bogdanov AA, Dontsova OA (2006). "Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA." J Mol Biol 364(1):26-31. PMID: 17010380


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Mon Jun 1, 2015, BIOCYC14B.