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Escherichia coli K-12 substr. MG1655 Reaction: 2.1.1.198

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions

EC Number: 2.1.1.198

Enzymes and Genes:
16S rRNA 2'-O-ribose C1402 methyltransferase Inferred from experiment : rsmI

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 16S rRNA (cytidine1402-2′-O)-methyltransferase

Enzyme Commission Synonyms: RsmI, YraL

Enzyme Commission Summary:
RsmI catalyses the 2-O-methylation of cytosine1402 and RsmH (EC 2.1.1.199) catalyses the N4-methylation of cytosine1402 in 16S rRNA. Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.

Citations: [Kimura10]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:2.1.1.198 , ENZYME:EC:2.1.1.198 , IUBMB-ExplorEnz:EC:2.1.1.198

Credits:
Created 24-Aug-2010 by Kothari A , SRI International


References

Kimura10: Kimura S, Suzuki T (2010). "Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA." Nucleic Acids Res 38(4):1341-52. PMID: 19965768


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Sat Aug 29, 2015, BIOCYC14A.