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Metabolic Modeling Tutorial
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Escherichia coli K-12 substr. MG1655 Reaction: 2.1.1.166

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions

EC Number: 2.1.1.166

Enzymes and Genes:
23S rRNA 2'-O-ribose U2552 methyltransferase Inferred from experiment : rlmE

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 23S rRNA (uridine2552-2′-O)-methyltransferase

Enzyme Commission Synonyms: Um(2552) 23S ribosomal RNA methyltransferase, heat shock protein RrmJ, RrmJ, FTSJ, Um2552 methyltransferase

Enzyme Commission Summary:
The enzyme catalyses the 2-O-methylation of the universally conserved uridine2552 in the A loop of 23S rRNA [Bugl00].

Citations: [Caldas00, Hager02, Hager04]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.1.1.166 , ENZYME:EC:2.1.1.166 , IUBMB-ExplorEnz:EC:2.1.1.166

Credits:
Created 04-Nov-2010 by Kothari A , SRI International


References

Bugl00: Bugl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U (2000). "RNA methylation under heat shock control." Mol Cell 6(2);349-60. PMID: 10983982

Caldas00: Caldas T, Binet E, Bouloc P, Costa A, Desgres J, Richarme G (2000). "The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase." J Biol Chem 275(22);16414-9. PMID: 10748051

Hager02: Hager J, Staker BL, Bugl H, Jakob U (2002). "Active site in RrmJ, a heat shock-induced methyltransferase." J Biol Chem 277(44);41978-86. PMID: 12181314

Hager04: Hager J, Staker BL, Jakob U (2004). "Substrate binding analysis of the 23S rRNA methyltransferase RrmJ." J Bacteriol 186(19);6634-42. PMID: 15375145


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13B.