Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateMacromolecule ReactionsPolynucleotide-ReactionsRNA-Reactions

EC Number:

Enzymes and Genes:
23S rRNA 2'-O-ribose U2552 methyltransferaseInferred from experiment: rlmE

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 23S rRNA (uridine2552-2′-O)-methyltransferase

Enzyme Commission Synonyms: Um(2552) 23S ribosomal RNA methyltransferase, heat shock protein RrmJ, RrmJ, FTSJ, Um2552 methyltransferase

Enzyme Commission Summary:
The enzyme catalyses the 2-O-methylation of the universally conserved uridine2552 in the A loop of 23S rRNA [Bugl00].

Citations: [Caldas00a, Hager02, Hager04]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 04-Nov-2010 by Kothari A, SRI International


Bugl00: Bugl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U (2000). "RNA methylation under heat shock control." Mol Cell 6(2);349-60. PMID: 10983982

Caldas00a: Caldas T, Binet E, Bouloc P, Costa A, Desgres J, Richarme G (2000). "The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase." J Biol Chem 275(22);16414-9. PMID: 10748051

Hager02: Hager J, Staker BL, Bugl H, Jakob U (2002). "Active site in RrmJ, a heat shock-induced methyltransferase." J Biol Chem 277(44);41978-86. PMID: 12181314

Hager04: Hager J, Staker BL, Jakob U (2004). "Substrate binding analysis of the 23S rRNA methyltransferase RrmJ." J Bacteriol 186(19);6634-42. PMID: 15375145

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.5 on Thu Nov 26, 2015, BIOCYC14B.