Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
putative nucleoside (IDP) diphosphatase: yibQ

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: nucleoside diphosphate phosphatase

Enzyme Commission Synonyms: nucleoside-diphosphatase, thiaminpyrophosphatase, UDPase, inosine diphosphatase, adenosine diphosphatase, IDPase, ADPase, adenosinepyrophosphatase, guanosine diphosphatase, guanosine 5'-diphosphatase, inosine 5'-diphosphatase, uridine diphosphatase, uridine 5'-diphosphatase, type B nucleoside diphosphatase, GDPase, CDPase, nucleoside 5'-diphosphatase, type L nucleoside diphosphatase, NDPase, nucleoside diphosphate phosphohydrolase

Enzyme Commission Summary:
Acts on IDP, GDP, UDP and also on D-ribose 5-diphosphate, but not on ADP.

Citations: [Uccelletti04, Failer02, Yeung00, Gibson55]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [a nucleoside diphosphate + H2O → a nucleoside 5'-monophosphate + phosphate + H+] (
i1: GDP + H2O → GMP + phosphate + H+ (

i2: UDP + H2O → UMP + phosphate + H+ (
i3: CDP + H2O → CMP + phosphate + H+ (

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created in MetaCyc 28-Feb-2011 by Zhang P, TAIR
Imported from MetaCyc 15-Dec-2011 by Keseler I, SRI International


Failer02: Failer BU, Braun N, Zimmermann H (2002). "Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase." J Biol Chem 277(40);36978-86. PMID: 12167635

Gibson55: Gibson DM, Ayengar P, Sanadi DR (1955). "A phosphatase specific for nucleoside diphosphates." Biochim Biophys Acta 16(4);536-8. PMID: 14389272

Uccelletti04: Uccelletti D, O'Callaghan C, Berninsone P, Zemtseva I, Abeijon C, Hirschberg CB (2004). "ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans." J Biol Chem 279(26);27390-8. PMID: 15102851

Yeung00: Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE (2000). "CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart." Biochemistry 39(42);12916-23. PMID: 11041856

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc14.