Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 2.8.1.7

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.8.1.7

Enzymes and Genes:
L-cysteine desulfurase Inferred from experiment : sufS
cysteine desulfurase Inferred from experiment : iscS

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: cysteine desulfurase

Enzyme Commission Synonyms: IscS, NIFS, NifS, SufS, cysteine desulfurylase

Sub-reactions:
an [L-cysteine desulfurase]-L-cysteine + L-cysteine → an [L-cysteine desulfurase] L-cysteine persulfide + L-alanine ,
an [L-cysteine desulfurase] L-cysteine persulfide + an unsulfurated [sulfur carrier] ↔ an [L-cysteine desulfurase]-L-cysteine + a sulfurated [sulfur carrier]

Enzyme Commission Summary:
A pyridoxal-phosphate protein. The sulfur from free L-cysteine is first transferred to a cysteine residue in the active site, and then passed on to various other acceptors. The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) [Mihara02]. In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation [Zheng93].

This is an overall reaction, which is composed of the two reactions listed above.

Citations: [Frazzon03]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.8.1.7 , ENZYME:EC:2.8.1.7 , IUBMB-ExplorEnz:EC:2.8.1.7

Credits:
Created 25-Aug-2011 by Caspi R , SRI International


References

Frazzon03: Frazzon J, Dean DR (2003). "Formation of iron-sulfur clusters in bacteria: an emerging field in bioinorganic chemistry." Curr Opin Chem Biol 7(2);166-73. PMID: 12714048

Mihara02: Mihara H, Esaki N (2002). "Bacterial cysteine desulfurases: their function and mechanisms." Appl Microbiol Biotechnol 60(1-2);12-23. PMID: 12382038

Zheng93: Zheng L, White RH, Cash VL, Jack RF, Dean DR (1993). "Cysteine desulfurase activity indicates a role for NIFS in metallocluster biosynthesis." Proc Natl Acad Sci U S A 90(7);2754-8. PMID: 8464885


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC14B.