Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
molybdopterin adenylyltransferaseInferred from experiment: mog

In Pathway: molybdenum cofactor biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: molybdopterin adenylyltransferase

Enzyme Commission Synonyms: MogA, Cnx1 (ambiguous)

Enzyme Commission Summary:
Catalyses the activation of molybdopterin for molybdenum insertion. In eukaryotes, this reaction is catalysed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase ( EC The reaction requires a divalent cation such as Mg2+ or Mn2+.

Citations: [Nichols05, Kuper00, Llamas04]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised in MetaCyc 14-Feb-2011 by Caspi R, SRI International
Imported from MetaCyc 13-Sep-2011 by Caspi R, SRI International


Kuper00: Kuper J, Palmer T, Mendel RR, Schwarz G (2000). "Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin binding, molybdenum insertion, and molybdenum cofactor stabilization." Proc Natl Acad Sci U S A 97(12);6475-80. PMID: 10823911

Llamas04: Llamas A, Mendel RR, Schwarz G (2004). "Synthesis of adenylated molybdopterin: an essential step for molybdenum insertion." J Biol Chem 279(53);55241-6. PMID: 15504727

Nichols05: Nichols JD, Rajagopalan KV (2005). "In vitro molybdenum ligation to molybdopterin using purified components." J Biol Chem 280(9);7817-22. PMID: 15632135

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Nov 26, 2015, biocyc11.