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Escherichia coli K-12 substr. MG1655 Reaction: 2.7.7.75

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.7.75

Enzymes and Genes:
MogA Inferred from experiment : mog

In Pathway: molybdenum cofactor biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: molybdopterin adenylyltransferase

Enzyme Commission Synonyms: MogA, Cnx1 (ambiguous)

Enzyme Commission Summary:
Catalyses the activation of molybdopterin for molybdenum insertion. In eukaryotes, this reaction is catalysed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). The reaction requires a divalent cation such as Mg2+ or Mn2+.

Citations: [Nichols05, Kuper00, Llamas04]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.7.7.75 , ENZYME:EC:2.7.7.75 , IUBMB-ExplorEnz:EC:2.7.7.75

Credits:
Revised in MetaCyc 14-Feb-2011 by Caspi R , SRI International
Imported from MetaCyc 13-Sep-2011 by Caspi R , SRI International


References

Kuper00: Kuper J, Palmer T, Mendel RR, Schwarz G (2000). "Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin binding, molybdenum insertion, and molybdenum cofactor stabilization." Proc Natl Acad Sci U S A 97(12);6475-80. PMID: 10823911

Llamas04: Llamas A, Mendel RR, Schwarz G (2004). "Synthesis of adenylated molybdopterin: an essential step for molybdenum insertion." J Biol Chem 279(53);55241-6. PMID: 15504727

Nichols05: Nichols JD, Rajagopalan KV (2005). "In vitro molybdenum ligation to molybdopterin using purified components." J Biol Chem 280(9);7817-22. PMID: 15632135


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Jan 30, 2015, biocyc14.