Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Escherichia coli K-12 substr. MG1655 Reaction: 2.5.1.31

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.5.1.31

Enzymes and Genes:
undecaprenyl diphosphate synthase Inferred from experiment : ispU

In Pathway: di-trans,poly-cis-undecaprenyl phosphate biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

Enzyme Commission Synonyms: di-trans,poly-cis-undecaprenyl-diphosphate synthase, undecaprenyl-diphosphate synthase, bactoprenyl-diphosphate synthase, UPP synθse, undecaprenyl diphosphate synθse, undecaprenyl pyrophosphate synθse, di-trans,poly-cis-decaprenylcistransferase

Enzyme Commission Summary:
Undecaprenyl pyrophosphate synthase catalyses the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall [Guo05].

Citations: [Muth84, Takahashi82a, Ko01, Fujikura03, Fujihashi01, Pan00, Kharel03]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.5.1.31 , ENZYME:EC:2.5.1.31 , IUBMB-ExplorEnz:EC:2.5.1.31


References

Fujihashi01: Fujihashi M, Zhang YW, Higuchi Y, Li XY, Koyama T, Miki K (2001). "Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase." Proc Natl Acad Sci U S A 98(8);4337-42. PMID: 11287651

Fujikura03: Fujikura K, Zhang YW, Fujihashi M, Miki K, Koyama T (2003). "Mutational analysis of allylic substrate binding site of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase." Biochemistry 42(14);4035-41. PMID: 12680756

Guo05: Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH (2005). "Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis." J Biol Chem 280(21);20762-74. PMID: 15788389

Kharel03: Kharel Y, Zhang YW, Fujihashi M, Miki K, Koyama T, Khare Y (2003). "Significance of highly conserved aromatic residues in Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase." J Biochem 134(6);819-26. PMID: 14769870

Ko01: Ko TP, Chen YK, Robinson H, Tsai PC, Gao YG, Chen AP, Wang AH, Liang PH (2001). "Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis." J Biol Chem 276(50);47474-82. PMID: 11581264

Muth84: Muth JD, Allen CM (1984). "Undecaprenyl pyrophosphate synthetase from Lactobacillus plantarum: a dimeric protein." Arch Biochem Biophys 230(1);49-60. PMID: 6712246

Pan00: Pan JJ, Chiou ST, Liang PH (2000). "Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reaction." Biochemistry 39(35);10936-42. PMID: 10978182

Takahashi82a: Takahashi I, Ogura K (1982). "Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase." J Biochem 92(5);1527-37. PMID: 6818223


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc11.