Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
undecaprenyl diphosphate synthaseInferred from experiment: ispU

In Pathway: di-trans,poly-cis-undecaprenyl phosphate biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

Enzyme Commission Synonyms: di-trans,poly-cis-undecaprenyl-diphosphate synthase, undecaprenyl-diphosphate synthase, bactoprenyl-diphosphate synthase, UPP synthetase, undecaprenyl diphosphate synthetase, undecaprenyl pyrophosphate synthetase, di-trans,poly-cis-decaprenylcistransferase

Enzyme Commission Summary:
Undecaprenyl pyrophosphate synthase catalyses the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall [Guo05].

Citations: [Muth84, Takahashi82a, Ko01 , Fujikura03, Fujihashi01, Pan00, Kharel03]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Fujihashi01: Fujihashi M, Zhang YW, Higuchi Y, Li XY, Koyama T, Miki K (2001). "Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase." Proc Natl Acad Sci U S A 98(8);4337-42. PMID: 11287651

Fujikura03: Fujikura K, Zhang YW, Fujihashi M, Miki K, Koyama T (2003). "Mutational analysis of allylic substrate binding site of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase." Biochemistry 42(14);4035-41. PMID: 12680756

Guo05: Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH (2005). "Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis." J Biol Chem 280(21);20762-74. PMID: 15788389

Kharel03: Kharel Y, Zhang YW, Fujihashi M, Miki K, Koyama T, Khare Y (2003). "Significance of highly conserved aromatic residues in Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase." J Biochem 134(6);819-26. PMID: 14769870

Ko01: Ko TP, Chen YK, Robinson H, Tsai PC, Gao YG, Chen AP, Wang AH, Liang PH (2001). "Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis." J Biol Chem 276(50);47474-82. PMID: 11581264

Muth84: Muth JD, Allen CM (1984). "Undecaprenyl pyrophosphate synthetase from Lactobacillus plantarum: a dimeric protein." Arch Biochem Biophys 230(1);49-60. PMID: 6712246

Pan00: Pan JJ, Chiou ST, Liang PH (2000). "Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reaction." Biochemistry 39(35);10936-42. PMID: 10978182

Takahashi82a: Takahashi I, Ogura K (1982). "Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase." J Biochem 92(5);1527-37. PMID: 6818223

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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