|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
Enzyme Commission Synonyms: di-trans,poly-cis-undecaprenyl-diphosphate synthase, undecaprenyl-diphosphate synthase, bactoprenyl-diphosphate synthase, UPP synθse, undecaprenyl diphosphate synθse, undecaprenyl pyrophosphate synθse, di-trans,poly-cis-decaprenylcistransferase
Enzyme Commission Summary:
Undecaprenyl pyrophosphate synthase catalyses the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall [Guo05].
Fujihashi01: Fujihashi M, Zhang YW, Higuchi Y, Li XY, Koyama T, Miki K (2001). "Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase." Proc Natl Acad Sci U S A 98(8);4337-42. PMID: 11287651
Fujikura03: Fujikura K, Zhang YW, Fujihashi M, Miki K, Koyama T (2003). "Mutational analysis of allylic substrate binding site of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase." Biochemistry 42(14);4035-41. PMID: 12680756
Guo05: Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH (2005). "Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis." J Biol Chem 280(21);20762-74. PMID: 15788389
Kharel03: Kharel Y, Zhang YW, Fujihashi M, Miki K, Koyama T, Khare Y (2003). "Significance of highly conserved aromatic residues in Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase." J Biochem 134(6);819-26. PMID: 14769870
Ko01: Ko TP, Chen YK, Robinson H, Tsai PC, Gao YG, Chen AP, Wang AH, Liang PH (2001). "Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis." J Biol Chem 276(50);47474-82. PMID: 11581264
Pan00: Pan JJ, Chiou ST, Liang PH (2000). "Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reaction." Biochemistry 39(35);10936-42. PMID: 10978182
Takahashi82a: Takahashi I, Ogura K (1982). "Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase." J Biochem 92(5);1527-37. PMID: 6818223
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