Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number:

Enzymes and Genes:
ribonucleoside-diphosphate reductase 2 Inferred from experiment Inferred by computational analysis : nrdE , nrdF
ribonucleoside diphosphate reductase 1 Inferred from experiment : nrdA , nrdB

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ribonucleoside-diphosphate reductase

Enzyme Commission Synonyms: ribonucleotide reductase, CDP reductase, ribonucleoside diphosphate reductase, UDP reductase, ADP reductase, nucleoside diphosphate reductase, ribonucleoside 5'-diphosphate reductase, ribonucleotide diphosphate reductase, 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase, RR

This reaction synthesizes deoxynucleoside diphosphates. Thioredoxin is the reductant cofactor and NADPH is the ultimate hydrogen donor.

Enzyme Commission Summary:
This enzyme is responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair. An iron protein. While the enzyme is activated by ATP, it is inhibited by dATP [Larsson66, Qiu06].

Citations: [Moore66, Larsson66a, Larsson73]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Larsson66: Larsson A, Reichard P (1966). "Enzymatic synthesis of deoxyribonucleotides. IX. Allosteric effects in the reduction of pyrimidine ribonucleotides by the ribonucleoside diphosphate reductase system of Escherichia coli." J Biol Chem 241(11);2533-9. PMID: 5330119

Larsson66a: Larsson A, Reichard P (1966). "Enzymatic synthesis of deoxyribonucleotides. X. Reduction of purine ribonucleotides; allosteric behavior and substrate specificity of the enzyme system from Escherichia coli B." J Biol Chem 241(11);2540-9. PMID: 5330120

Larsson73: Larsson A (1973). "Ribonucleotide reductase from regenerating rat liver. II. Substrate phosphorylation level and effect of deoxyadenosine triphosphate." Biochim Biophys Acta 324(4);447-51. PMID: 4543472

Moore66: Moore EC, Hurlbert RB (1966). "Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors." J Biol Chem 241(20);4802-9. PMID: 5926184

Qiu06: Qiu W, Zhou B, Darwish D, Shao J, Yen Y (2006). "Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits." Biochem Biophys Res Commun 340(2);428-34. PMID: 16376858

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Tue Oct 6, 2015, biocyc13.