Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
bacterioferritin: bfr
multicopper oxidase with role in copper homeostasisInferred from experiment: cueO

Reaction Locations: periplasm (sensu Gram-negative Bacteria), cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ferroxidase

Enzyme Commission Synonyms: ceruloplasmin, caeruloplasmin, ferroxidase I, iron oxidase, iron(II):oxygen oxidoreductase, ferro:O2 oxidoreductase, iron II:oxygen oxidoreductase, hephaestin, HEPH

Enzyme Commission Summary:
The enzyme in blood plasma (ceruloplasmin) belongs to the family of multicopper oxidases. In humans it accounts for 95% of plasma copper. It oxidizes Fe(II) to Fe(III), which allows the subsequent incorporation of the latter into proteins such as apotransferrin and lactoferrin. An enzyme from iron oxidizing bacterium strain TI-1 contains heme a.

Citations: [Osaki66, Osaki67, Chen04, Takai01 ]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Chen04: Chen H, Attieh ZK, Su T, Syed BA, Gao H, Alaeddine RM, Fox TC, Usta J, Naylor CE, Evans RW, McKie AT, Anderson GJ, Vulpe CD (2004). "Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice." Blood 103(10);3933-9. PMID: 14751926

Osaki66: Osaki S (1966). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)." J Biol Chem 241(21);5053-9. PMID: 5925868

Osaki67: Osaki S, Walaas O (1967). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase. II. Rate constants at various steps and formation of a possible enzyme-substrate complex." J Biol Chem 242(11);2653-7. PMID: 6027241

Takai01: Takai M, Kamimura K, Sugio T (2001). "A new iron oxidase from a moderately thermophilic iron oxidizing bacterium strain TI-1." Eur J Biochem 268(6);1653-8. PMID: 11248684

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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