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Metabolic Modeling Tutorial
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Escherichia coli K-12 substr. MG1655 Reaction: 2.1.1.144

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.1.1.144

Enzymes and Genes:
trans-aconitate 2-methyltransferase Inferred from experiment : tam

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: trans-aconitate 2-methyltransferase

Enzyme Commission Summary:
Also catalyzes the formation of the methyl monoester of cis- aconitate, isocitrate and citrate, but more slowly.
While the enzyme from Escherichia coli forms (E)-3- (methoxycarbonyl)-pent-2-enedioate as the product, that from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl) butenedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.145).

Citations: [Cai01, Cai01a, Cai99]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.1.1.144 , ENZYME:EC:2.1.1.144 , IUBMB-ExplorEnz:EC:2.1.1.144


References

Cai01: Cai H, Strouse J, Dumlao D, Jung ME, Clarke S (2001). "Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases." Biochemistry 40(7);2210-9. PMID: 11329290

Cai01a: Cai H, Dumlao D, Katz JE, Clarke S (2001). "Identification of the gene and characterization of the activity of the trans-aconitate methyltransferase from Saccharomyces cerevisiae." Biochemistry 40(45);13699-709. PMID: 11695919

Cai99: Cai H, Clarke S (1999). "A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli." J Biol Chem 274(19);13470-9. PMID: 10224113


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC14A.