Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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Escherichia coli K-12 substr. MG1655 Reaction: 1.6.5.10

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.6.5.10

Enzymes and Genes:
NADPH quinone reductase Inferred from experiment : mdaB
chromate reductase : yieF
NAD(P)H:quinone oxidoreductase : wrbA
regulator of KefC-mediated potassium transport and quinone oxidoreductase : kefF

Supersedes EC number: 1.6.99.6

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
a quinone + NAD(P)H + H+ → a quinol + NAD(P)+ (1.6.5.2)

Enzyme Commission Primary Name: NADPH dehydrogenase (quinone)

Enzyme Commission Synonyms: reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase, NADPH oxidase, NADPH2 dehydrogenase (quinone)

Enzyme Commission Summary:
A flavoprotein [Koli69, Hayashi90]. The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors [Hayashi96]. Menaquinone can act as acceptor. The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol [Koli69].

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.6.5.10 , ENZYME:EC:1.6.5.10 , IUBMB-ExplorEnz:EC:1.6.5.10


References

Hayashi90: Hayashi M, Hasegawa K, Oguni Y, Unemoto T (1990). "Characterization of FMN-dependent NADH-quinone reductase induced by menadione in Escherichia coli." Biochim Biophys Acta 1990;1035(2);230-6. PMID: 2118386

Hayashi96: Hayashi M, Ohzeki H, Shimada H, Unemoto T (1996). "NADPH-specific quinone reductase is induced by 2-methylene-4-butyrolactone in Escherichia coli." Biochim Biophys Acta 1273(2);165-70. PMID: 8611590

Koli69: Koli AK, Yearby C, Scott W, Donaldson KO (1969). "Purification and properties of three separate menadione reductases from hog liver." J Biol Chem 244(4);621-9. PMID: 4388793


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC14A.