|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
In Pathway: L-carnitine degradation I
Supersedes EC number: 220.127.116.11
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: L-carnitine CoA-transferase
Enzyme Commission Synonyms: CaiB, crotonobetainyl/γ-butyrobetainyl-CoA:carnitine CoA-transferase
Enzyme Commission Summary:
The enzyme is found in gammaproteobacteria such as Proteus sp. and Escherichia coli. It has similar activity with both substrates.
Elssner01: Elssner T, Engemann C, Baumgart K, Kleber HP (2001). "Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli." Biochemistry 40(37);11140-8. PMID: 11551212
Engemann05: Engemann C, Elssner T, Pfeifer S, Krumbholz C, Maier T, Kleber HP (2005). "Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp." Arch Microbiol 183(3);176-89. PMID: 15731894
Rangarajan05: Rangarajan ES, Li Y, Iannuzzi P, Cygler M, Matte A (2005). "Crystal structure of Escherichia coli crotonobetainyl-CoA: carnitine CoA-transferase (CaiB) and its complexes with CoA and carnitinyl-CoA." Biochemistry 44(15);5728-38. PMID: 15823031
©2016 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493