Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 2.8.3.21

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.8.3.21

Enzymes and Genes:
γ-butyrobetainyl-CoA:carnitine CoA transferase Inferred from experiment : caiB

In Pathway: L-carnitine degradation I

Supersedes EC number: 4.2.1.89

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: L-carnitine CoA-transferase

Enzyme Commission Synonyms: CaiB, crotonobetainyl/γ-butyrobetainyl-CoA:carnitine CoA-transferase

Enzyme Commission Summary:
The enzyme is found in gammaproteobacteria such as Proteus sp. and Escherichia coli. It has similar activity with both substrates.

Citations: [Engemann01, Elssner01, Stenmark04, Engemann05, Rangarajan05]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.8.3.21 , ENZYME:EC:2.8.3.21 , IUBMB-ExplorEnz:EC:2.8.3.21


References

Elssner01: Elssner T, Engemann C, Baumgart K, Kleber HP (2001). "Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli." Biochemistry 40(37);11140-8. PMID: 11551212

Engemann01: Engemann C, Elssner T, Kleber HP (2001). "Biotransformation of crotonobetaine to L(-)-carnitine in Proteus sp." Arch Microbiol 175(5);353-9. PMID: 11409545

Engemann05: Engemann C, Elssner T, Pfeifer S, Krumbholz C, Maier T, Kleber HP (2005). "Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp." Arch Microbiol 183(3);176-89. PMID: 15731894

Rangarajan05: Rangarajan ES, Li Y, Iannuzzi P, Cygler M, Matte A (2005). "Crystal structure of Escherichia coli crotonobetainyl-CoA: carnitine CoA-transferase (CaiB) and its complexes with CoA and carnitinyl-CoA." Biochemistry 44(15);5728-38. PMID: 15823031

Stenmark04: Stenmark P, Gurmu D, Nordlund P (2004). "Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism." Biochemistry 43(44);13996-4003. PMID: 15518548


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC14B.