|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
In Pathway: ADP-L-glycero-β-D-manno-heptose biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: D-sedoheptulose 7-phosphate isomerase
Enzyme Commission Synonyms: sedoheptulose-7-phosphate isomerase, phosphoheptose isomerase, gmhA (gene name), lpcA (gene name)
Enzyme Commission Summary:
In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-β-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core. In Gram-positive bacteria the enzyme is involved in biosynthesis of GDP-D-glycero-α-D-manno-heptose, which is required for assembly of S-layer glycoprotein.
Kim09c: Kim MS, Shin DH (2009). "A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei." Acta Crystallogr Sect F Struct Biol Cryst Commun 65(Pt 11);1110-2. PMID: 19923728
Kneidinger02: Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P (2002). "Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli." J Bacteriol 184(2);363-9. PMID: 11751812
Taylor08a: Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS (2008). "Structure and function of GmhA (sedoheptulose 7-phosphate isomerase): A critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants." J Biol Chem 283(5):2835-45. PMID: 18056714
Valvano02: Valvano MA, Messner P, Kosma P (2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides." Microbiology 148(Pt 7);1979-89. PMID: 12101286
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