|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase : rfaE
In Pathway: ADP-L-glycero-β-D-manno-heptose biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase
Enzyme Commission Synonyms: D-β-D-heptose 7-phosphate kinase/D-β-D-heptose 1-phosphate adenylyltransferase, D-glycero-D-manno-heptose-1β-phosphate adenylyltransferase, hldE (gene name), rfaE (gene name)
Enzyme Commission Summary:
The bifunctional protein hldE includes D-glycero-β-D-manno-heptose-7-phosphate kinase and D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 22.214.171.124). The enzyme is involved in biosynthesis of ADP-L-glycero-&beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria.
Kneidinger02: Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P (2002). "Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli." J Bacteriol 184(2);363-9. PMID: 11751812
Valvano00: Valvano MA, Marolda CL, Bittner M, Glaskin-Clay M, Simon TL, Klena JD (2000). "The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose." J Bacteriol 182(2);488-97. PMID: 10629197
Valvano02: Valvano MA, Messner P, Kosma P (2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides." Microbiology 148(Pt 7);1979-89. PMID: 12101286
Wang10c: Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D (2010). "Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)." Biochemistry 49(6);1072-81. PMID: 20050615
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