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Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
nucleoside triphosphate pyrophosphataseInferred from experiment: yhdE
pyrimidine deoxynucleoside triphosphate pyrophosphohydrolaseInferred from experiment: nudI
nucleoside triphosphate pyrophosphohydrolase: mazG

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: nucleoside-triphosphate diphosphatase

Enzyme Commission Synonyms: nucleoside-triphosphate pyrophosphatase

Enzyme Commission Summary:
May be identical with EC nucleotide diphosphatase.

Citations: [Chern69, Zhang02a]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [a nucleoside triphosphate + H2O → a nucleoside 5'-monophosphate + diphosphate + H+] (
i1: dGTP + H2O → dGMP + diphosphate + H+ (

i2: dATP + H2O → dAMP + diphosphate + H+ (

i3: dUTP + H2O → dUMP + diphosphate + H+ (

i4: XTP + H2O → XMP + diphosphate + H+ (

i5: CTP + H2O → CMP + diphosphate + H+ (

i6: dITP + H2O → dIMP + diphosphate + H+ (

i7: ATP + H2O → AMP + diphosphate + H+ (

i8: ITP + H2O → IMP + diphosphate + H+ (

i9: dCTP + H2O → dCMP + diphosphate + H+ (

i10: UTP + H2O → UMP + diphosphate + H+ (

i11: dTTP + H2O → dTMP + diphosphate + H+ (

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Chern69: Chern CJ, MacDonald AB, Morris AJ (1969). "Purification and properties of a nucleoside triphosphate pyrophosphohydrolase from red cells of the rabbit." J Biol Chem 244(20);5489-95. PMID: 4310599

Zhang02a: Zhang J, Inouye M (2002). "MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli." J Bacteriol 184(19);5323-9. PMID: 12218018

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Feb 11, 2016, biocyc12.