|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: nucleoside-triphosphate diphosphatase
Enzyme Commission Synonyms: nucleoside-triphosphate pyrophosphatase
Enzyme Commission Summary:
May be identical with EC 22.214.171.124 nucleotide diphosphatase.
Instance reactions of [a nucleoside triphosphate + H2O → a nucleoside 5'-monophosphate + diphosphate + H+] (126.96.36.199):
i1: dATP + H2O → dAMP + diphosphate + H+ (188.8.131.52)
i2: dUTP + H2O → dUMP + diphosphate + H+ (184.108.40.206/220.127.116.11)
i3: XTP + H2O → XMP + diphosphate + H+ (18.104.22.168)
i4: CTP + H2O → CMP + diphosphate + H+ (22.214.171.124/126.96.36.199)
i5: dITP + H2O → dIMP + diphosphate + H+ (188.8.131.52)
i6: ATP + H2O → AMP + diphosphate + H+ (184.108.40.206)
i7: ITP + H2O → IMP + diphosphate + H+ (220.127.116.11)
i8: dCTP + H2O → dCMP + diphosphate + H+ (18.104.22.168/22.214.171.124/126.96.36.199)
i9: UTP + H2O → UMP + diphosphate + H+ (188.8.131.52)
i10: dTTP + H2O → dTMP + diphosphate + H+ (184.108.40.206)
i11: dGTP + H2O → dGMP + diphosphate + H+ (220.127.116.11)
Chern69: Chern CJ, MacDonald AB, Morris AJ (1969). "Purification and properties of a nucleoside triphosphate pyrophosphohydrolase from red cells of the rabbit." J Biol Chem 244(20);5489-95. PMID: 4310599
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