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Escherichia coli K-12 substr. MG1655 Reaction: 2.7.7.41


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.7.7.41

Enzymes and Genes:
CDP-diglyceride synthetaseInferred from experiment: cdsA

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
CTP + a 1,2-diacyl-sn-glycerol 3-phosphate + H+ → a CDP-diacylglycerol + diphosphate (2.7.7.41)

Enzyme Commission Primary Name: phosphatidate cytidylyltransferase

Enzyme Commission Synonyms: CDP diglyceride pyrophosphorylase, CDP-diacylglycerol synthase, CDP-diacylglyceride synthetase, cytidine diphosphoglyceride pyrophosphorylase, phosphatidate cytidyltransferase, phosphatidic acid cytidylyltransferase, CTP:1,2-diacylglycerophosphate-cytidyl transferase, CTP-diacylglycerol synthetase, DAG synthetase, CDP-DG

Summary:
This reaction is part of the phospholipid biosynthesis pathway.

Citations: [McCaman68, Petzold67, Carter66]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [CTP + a 1,2-diacyl-sn-glycerol 3-phosphate + H+ → a CDP-diacylglycerol + diphosphate] (2.7.7.41):
i1: CTP + a 2,3,4-saturated L-phosphatidate + H+ → a CDP-2,3,4-saturated-diacylglycerol + diphosphate (2.7.7.41)

Relationship Links: BRENDA:EC:2.7.7.41, ENZYME:EC:2.7.7.41, IUBMB-ExplorEnz:EC:2.7.7.41


References

Carter66: Carter JR, Kennedy EP (1966). "Enzymatic synthesis of cytidine diphosphate diglyceride." J Lipid Res 7(5);678-83. PMID: 4291255

McCaman68: McCaman RE, Finnerty WR (1968). "Biosynthesis of cytidine diphosphate-diglyceride by a particulate fracgion from Micrococcus cerificans." J Biol Chem 243(19);5074-80. PMID: 5679981

Petzold67: Petzold GL, Agranoff BW (1967). "The biosynthesis of cytidine diphosphate diglyceride by embryonic chick brain." J Biol Chem 242(6);1187-91. PMID: 6067194


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon May 2, 2016, biocyc14.