Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
CDP-diglyceride synthetase Inferred from experiment : cdsA

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
CTP + a 1,2-diacyl-sn-glycerol 3-phosphate + H+ → a CDP-diacylglycerol + diphosphate (

Enzyme Commission Primary Name: phosphatidate cytidylyltransferase

Enzyme Commission Synonyms: CDP diglyceride pyrophosphorylase, CDP-diacylglycerol synthase, CDP-diacylglyceride synθse, cytidine diphosphoglyceride pyrophosphorylase, phosphatidate cytidyltransferase, phosphatidic acid cytidylyltransferase, CTP:1,2-diacylglycerophosphate-cytidyl transferase, CTP-diacylglycerol synθse, DAG synθse, CDP-DG

This reaction is part of the phospholipid biosynthesis pathway.

Citations: [McCaman68, Petzold67, Carter66]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [CTP + a 1,2-diacyl-sn-glycerol 3-phosphate + H+ → a CDP-diacylglycerol + diphosphate] (
i1: CTP + a 2,3,4-saturated L-phosphatidate + H+ → a CDP-2,3,4-saturated-diacylglycerol + diphosphate (

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Carter66: Carter JR, Kennedy EP (1966). "Enzymatic synthesis of cytidine diphosphate diglyceride." J Lipid Res 7(5);678-83. PMID: 4291255

McCaman68: McCaman RE, Finnerty WR (1968). "Biosynthesis of cytidine diphosphate-diglyceride by a particulate fracgion from Micrococcus cerificans." J Biol Chem 243(19);5074-80. PMID: 5679981

Petzold67: Petzold GL, Agranoff BW (1967). "The biosynthesis of cytidine diphosphate diglyceride by embryonic chick brain." J Biol Chem 242(6);1187-91. PMID: 6067194

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Fri Oct 9, 2015, BIOCYC14B.