Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Escherichia coli K-12 substr. MG1655 Reaction: 4.99.1.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.99.1.1

Enzymes and Genes:
ferrochelatase Inferred from experiment : hemH

In Pathway: heme biosynthesis I (aerobic) , superpathway of heme biosynthesis from uroporphyrinogen-III , heme biosynthesis II (anaerobic)

Reaction Locations: periplasmic space (sensu Gram-negative Bacteria), cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ferrochelatase

Enzyme Commission Synonyms: ferro-protoporphyrin chelatase, iron chelatase, heme synθse, heme synthase, protoheme ferro-lyase

Summary:
This is the last reaction in protoheme biosynthesis.

Citations: [PORRA63, PORRA63a, Bloomer87]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:4.99.1.1 , ENZYME:EC:4.99.1.1 , IUBMB-ExplorEnz:EC:4.99.1.1


References

Bloomer87: Bloomer JR, Hill HD, Morton KO, Anderson-Burnham LA, Straka JG (1987). "The enzyme defect in bovine protoporphyria. Studies with purified ferrochelatase." J Biol Chem 262(2);667-71. PMID: 3805002

PORRA63: PORRA RJ, JONES OT (1963). "Studies on ferrochelatase. 2. An in vestigation of the role offerrochelatase in the biosynthesis of various haem prosthetic groups." Biochem J 87;186-92. PMID: 13972329

PORRA63a: PORRA RJ, JONES OT (1963). "Studies on ferrochelatase. 1. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract." Biochem J 87;181-5. PMID: 13972328


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 21, 2014, biocyc14.