|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Reaction Locations: periplasmic space (sensu Gram-negative Bacteria), cytosol
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: ferrochelatase
Enzyme Commission Synonyms: ferro-protoporphyrin chelatase, iron chelatase, heme synθse, heme synthase, protoheme ferro-lyase
This is the last reaction in protoheme biosynthesis.
Bloomer87: Bloomer JR, Hill HD, Morton KO, Anderson-Burnham LA, Straka JG (1987). "The enzyme defect in bovine protoporphyria. Studies with purified ferrochelatase." J Biol Chem 262(2);667-71. PMID: 3805002
PORRA63: PORRA RJ, JONES OT (1963). "Studies on ferrochelatase. 2. An in vestigation of the role offerrochelatase in the biosynthesis of various haem prosthetic groups." Biochem J 87;186-92. PMID: 13972329
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