Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
porphyrinogen peroxidaseInferred from experiment: yfeX
EfeB dimerInferred from experiment: efeB
ferrochelataseInferred from experiment: hemH

In Pathway: heme biosynthesis I (aerobic), superpathway of heme biosynthesis from uroporphyrinogen-III, heme biosynthesis II (anaerobic)

Reaction Locations: periplasm (sensu Gram-negative Bacteria), cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ferrochelatase

Enzyme Commission Synonyms: ferro-protoporphyrin chelatase, iron chelatase (ambiguous), heme synthetase (ambiguous), heme synthase (ambiguous), protoheme ferro-lyase

This is the last reaction in protoheme biosynthesis.

Citations: [PORRA63, PORRA63a, Bloomer87]

Gene-Reaction Schematic

Expand/Contract the Schematic connections:

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Bloomer87: Bloomer JR, Hill HD, Morton KO, Anderson-Burnham LA, Straka JG (1987). "The enzyme defect in bovine protoporphyria. Studies with purified ferrochelatase." J Biol Chem 262(2);667-71. PMID: 3805002

PORRA63: PORRA RJ, JONES OT (1963). "Studies on ferrochelatase. 2. An in vestigation of the role offerrochelatase in the biosynthesis of various haem prosthetic groups." Biochem J 87;186-92. PMID: 13972329

PORRA63a: PORRA RJ, JONES OT (1963). "Studies on ferrochelatase. 1. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract." Biochem J 87;181-5. PMID: 13972328

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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