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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
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Escherichia coli K-12 substr. MG1655 Reaction: 4.99.1.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.99.1.1

Enzymes and Genes:
ferrochelatase Inferred from experiment : hemH

In Pathway: heme biosynthesis I (aerobic) , superpathway of heme biosynthesis from uroporphyrinogen-III , heme biosynthesis II (anaerobic)

Reaction Locations: periplasmic space (sensu Gram-negative Bacteria), cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ferrochelatase

Enzyme Commission Synonyms: ferro-protoporphyrin chelatase, iron chelatase, heme synθse, heme synthase, protoheme ferro-lyase

Summary:
This is the last reaction in protoheme biosynthesis.

Citations: [PORRA63, PORRA63a, Bloomer87]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:4.99.1.1 , ENZYME:EC:4.99.1.1 , IUBMB-ExplorEnz:EC:4.99.1.1


References

Bloomer87: Bloomer JR, Hill HD, Morton KO, Anderson-Burnham LA, Straka JG (1987). "The enzyme defect in bovine protoporphyria. Studies with purified ferrochelatase." J Biol Chem 262(2);667-71. PMID: 3805002

PORRA63: PORRA RJ, JONES OT (1963). "Studies on ferrochelatase. 2. An in vestigation of the role offerrochelatase in the biosynthesis of various haem prosthetic groups." Biochem J 87;186-92. PMID: 13972329

PORRA63a: PORRA RJ, JONES OT (1963). "Studies on ferrochelatase. 1. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract." Biochem J 87;181-5. PMID: 13972328


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, BIOCYC14B.