|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 126.96.36.199
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Marked as unbalanced.
Enzyme Commission Primary Name: ferric-chelate reductase (NADPH)
Enzyme Commission Synonyms: ferric chelate reductase (ambiguous), iron chelate reductase (ambiguous), NADPH:Fe3+-EDTA reductase, NADPH-dependent ferric reductase, yqjH (gene name), Fe(II):NADP+ oxidoreductase
Enzyme Commission Summary:
Contains FAD. The reaction is catalysed in the reverse direction. The enzyme, which is widespread among bacteria, catalyses the reduction and release of iron from a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate. The enzyme from Escherichia coli has the highest efficiency with the hydrolysed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine [Miethke11].
Bamford08: Bamford VA, Armour M, Mitchell SA, Cartron M, Andrews SC, Watson KA (2008). "Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase." Acta Crystallogr Sect F Struct Biol Cryst Commun 64(Pt 9);792-6. PMID: 18765906
Miethke11: Miethke M, Hou J, Marahiel MA (2011). "The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli." Biochemistry 50(50);10951-64. PMID: 22098718
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