Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
ferric reductase, NADPH-dependentInferred from experiment: yqjH

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: ferric-chelate reductase (NADPH)

Enzyme Commission Synonyms: ferric chelate reductase (ambiguous), iron chelate reductase (ambiguous), NADPH:Fe3+-EDTA reductase, NADPH-dependent ferric reductase, yqjH (gene name), Fe(II):NADP+ oxidoreductase

Enzyme Commission Summary:
Contains FAD. The reaction is catalysed in the reverse direction. The enzyme, which is widespread among bacteria, catalyses the reduction and release of iron from a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate. The enzyme from Escherichia coli has the highest efficiency with the hydrolysed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine [Miethke11].

Citations: [Bamford08, Wang11b]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 29-Nov-2010 by Keseler I, SRI International


Bamford08: Bamford VA, Armour M, Mitchell SA, Cartron M, Andrews SC, Watson KA (2008). "Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase." Acta Crystallogr Sect F Struct Biol Cryst Commun 64(Pt 9);792-6. PMID: 18765906

Miethke11: Miethke M, Hou J, Marahiel MA (2011). "The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli." Biochemistry 50(50);10951-64. PMID: 22098718

Wang11b: Wang S, Wu Y, Outten FW (2011). "Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli." J Bacteriol 193(2);563-74. PMID: 21097627

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu May 5, 2016, biocyc13.