|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.
Reaction Locations: periplasmic space (sensu Gram-negative Bacteria)
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: phospholipase A2
Enzyme Commission Synonyms: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A
Enzyme Commission Summary:
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
Doery61: Doery HM, Pearson JE (1961). "Haemolysins in venoms of Australian snakes. Observations on the haemolysins of the venoms of some Australian snakes and the separation of phospholipase A from the venom of Pseudechis porphyriacus." Biochem J 78;820-7. PMID: 13723433
Hanahan60: Hanahan DJ, Brockerheff H, Barron EJ (1960). "The site of attack of phospholipase (lecithinase) A on lecithin: a re-evaluation. Position of fatty acids on lecithins and triglycerides." J Biol Chem 235;1917-23. PMID: 14399412
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