Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
outer membrane phospholipase Inferred from experiment : pldA

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

Reaction Locations: periplasmic space (sensu Gram-negative Bacteria)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phospholipase A2

Enzyme Commission Synonyms: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A

Enzyme Commission Summary:
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.

Citations: [Doery61, FraenkelConrat50, Hanahan60, Moore64, Saito62, vandenBosch80]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Created 05-Oct-2011 by Mackie A , Macquarie University


Doery61: Doery HM, Pearson JE (1961). "Haemolysins in venoms of Australian snakes. Observations on the haemolysins of the venoms of some Australian snakes and the separation of phospholipase A from the venom of Pseudechis porphyriacus." Biochem J 78;820-7. PMID: 13723433

FraenkelConrat50: Fraenkel-Conrat H, Fraenkel-Conrat J (1950). "Inactivation of crotoxin by group-specific reagents." Biochim Biophys Acta 5(1);98-104. PMID: 15433984

Hanahan60: Hanahan DJ, Brockerheff H, Barron EJ (1960). "The site of attack of phospholipase (lecithinase) A on lecithin: a re-evaluation. Position of fatty acids on lecithins and triglycerides." J Biol Chem 235;1917-23. PMID: 14399412

Moore64: Moore JH, Williams DL (1964). "Some observations on the specificity of phospholipase A." Biochim Biophys Acta 84;41-54. PMID: 14124755

Saito62: Saito K, Hanahan DJ (1962). "A study of the purification and properties of the phospholipase A of Crotalus admanteus venom." Biochemistry 1;521-32. PMID: 14496116

vandenBosch80: van den Bosch H (1980). "Intracellular phospholipases A." Biochim Biophys Acta 604(2);191-246. PMID: 6252969

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Tue Oct 13, 2015, biocyc13.