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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 3.1.1.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.1.4

Enzymes and Genes:
outer membrane phospholipase Inferred from experiment : pldA

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

Reaction Locations: periplasmic space (sensu Gram-negative Bacteria)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phospholipase A2

Enzyme Commission Synonyms: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A

Enzyme Commission Summary:
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.

Citations: [DOERY61, FRAENKELCONRAT50, HANAHAN60, MOORE64, SAITO62, vandenBosch80]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.1.1.4 , ENZYME:EC:3.1.1.4 , IUBMB-ExplorEnz:EC:3.1.1.4

Credits:
Created 05-Oct-2011 by Mackie A , Macquarie University


References

DOERY61: DOERY HM, PEARSON JE (1961). "Haemolysins in venoms of Australian snakes. Observations on the haemolysins of the venoms of some Australian snakes and the separation of phospholipase A from the venom of Pseudechis porphyriacus." Biochem J 78;820-7. PMID: 13723433

FRAENKELCONRAT50: FRAENKEL-CONRAT H, FRAENKEL-CONRAT J (1950). "Inactivation of crotoxin by group-specific reagents." Biochim Biophys Acta 5(1);98-104. PMID: 15433984

HANAHAN60: HANAHAN DJ, BROCKERHOFF H, BARRON EJ (1960). "The site of attack of phospholipase (lecithinase) A on lecithin: a re-evaluation. Position of fatty acids on lecithins and triglycerides." J Biol Chem 235;1917-23. PMID: 14399412

MOORE64: MOORE JH, WILLIAMS DL (1964). "SOME OBSERVATIONS ON THE SPECIFICITY OF PHOSPHOLIPASE A." Biochim Biophys Acta 84;41-54. PMID: 14124755

SAITO62: SAITO K, HANAHAN DJ (1962). "A study of the purification and properties of the phospholipase A of Crotalus admanteus venom." Biochemistry 1;521-32. PMID: 14496116

vandenBosch80: van den Bosch H (1980). "Intracellular phospholipases A." Biochim Biophys Acta 604(2);191-246. PMID: 6252969


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, biocyc12.