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Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
outer membrane phospholipaseInferred from experiment: pldA

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

Reaction Locations: periplasm (sensu Gram-negative Bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phospholipase A2

Enzyme Commission Synonyms: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A

Enzyme Commission Summary:
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.

Citations: [Doery61, FraenkelConrat50, Hanahan60, Moore64, Saito62, vandenBosch80]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 05-Oct-2011 by Mackie A, Macquarie University


Doery61: Doery HM, Pearson JE (1961). "Haemolysins in venoms of Australian snakes. Observations on the haemolysins of the venoms of some Australian snakes and the separation of phospholipase A from the venom of Pseudechis porphyriacus." Biochem J 78;820-7. PMID: 13723433

FraenkelConrat50: Fraenkel-Conrat H, Fraenkel-Conrat J (1950). "Inactivation of crotoxin by group-specific reagents." Biochim Biophys Acta 5(1);98-104. PMID: 15433984

Hanahan60: Hanahan DJ, Brockerheff H, Barron EJ (1960). "The site of attack of phospholipase (lecithinase) A on lecithin: a re-evaluation. Position of fatty acids on lecithins and triglycerides." J Biol Chem 235;1917-23. PMID: 14399412

Moore64: Moore JH, Williams DL (1964). "Some observations on the specificity of phospholipase A." Biochim Biophys Acta 84;41-54. PMID: 14124755

Saito62: Saito K, Hanahan DJ (1962). "A study of the purification and properties of the phospholipase A of Crotalus admanteus venom." Biochemistry 1;521-32. PMID: 14496116

vandenBosch80: van den Bosch H (1980). "Intracellular phospholipases A." Biochim Biophys Acta 604(2);191-246. PMID: 6252969

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun May 1, 2016, biocyc14.