Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Supersedes EC numbers:,,,,,,

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: cytosol nonspecific dipeptidase

Enzyme Commission Synonyms: N2-β-alanylarginine dipeptidase, glycyl-leucine dipeptidase, peptidase A, Pro-X dipeptidase, prolyl dipeptidase, iminodipeptidase, prolinase, L-prolylglycine dipeptidase, prolylglycine dipeptidase, diglycinase, Gly-Leu hydrolase, glycyl-L-leucine dipeptidase, glycyl-L-leucine peptidase, L-amino-acyl-L-amino-acid hydrolase, glycylleucine peptidase, glycylleucine hydrolase, glycylleucine dipeptide hydrolase, non-specific dipeptidase, human cytosolic non-specific dipeptidase, glycyl-L-leucine hydrolase, glycyl-glycine dipeptidase

This reaction is needed because automated instantiation of this case fails for the generic version a dipeptide + H2O → 2 a standard α amino acid.

Enzyme Commission Summary:
This enzyme catalyzes the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids. It is a zinc enzyme with broad specificity, varying somewhat with source species. Activated and stabilized by dithiothreitol and Mn2+. Inhibited by bestatin and leucine.

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 07-May-2012 by Krummenacker M, SRI International

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Dec 1, 2015, biocyc12.