|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Supersedes EC numbers: 18.104.22.168, 22.214.171.124, 126.96.36.199, 188.8.131.52, 184.108.40.206, 220.127.116.11, 18.104.22.168
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: cytosol nonspecific dipeptidase
Enzyme Commission Synonyms: N2-β-alanylarginine dipeptidase, glycyl-leucine dipeptidase, peptidase A, Pro-X dipeptidase, prolyl dipeptidase, iminodipeptidase, prolinase, L-prolylglycine dipeptidase, prolylglycine dipeptidase, diglycinase, Gly-Leu hydrolase, glycyl-L-leucine dipeptidase, glycyl-L-leucine peptidase, L-amino-acyl-L-amino-acid hydrolase, glycylleucine peptidase, glycylleucine hydrolase, glycylleucine dipeptide hydrolase, non-specific dipeptidase, human cytosolic non-specific dipeptidase, glycyl-L-leucine hydrolase, glycyl-glycine dipeptidase
This reaction is needed because automated instantiation of this case fails for the generic version a dipeptide + H2O → 2 a standard α amino acid.
Enzyme Commission Summary:
This enzyme catalyzes the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids. It is a zinc enzyme with broad specificity, varying somewhat with source species. Activated and stabilized by dithiothreitol and Mn2+. Inhibited by bestatin and leucine.
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