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Escherichia coli K-12 substr. MG1655 Reaction: 3.4.13.18

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.13.18

Supersedes EC numbers: 3.4.3.6, 3.4.3.2, 3.4.3.1, 3.4.13.15, 3.4.13.8, 3.4.13.2, 3.4.13.1

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: cytosol nonspecific dipeptidase

Enzyme Commission Synonyms: N2-β-alanylarginine dipeptidase, glycyl-leucine dipeptidase, peptidase A, Pro-X dipeptidase, prolyl dipeptidase, iminodipeptidase, prolinase, L-prolylglycine dipeptidase, prolylglycine dipeptidase, diglycinase, Gly-Leu hydrolase, glycyl-L-leucine dipeptidase, glycyl-L-leucine peptidase, L-amino-acyl-L-amino-acid hydrolase, glycylleucine peptidase, glycylleucine hydrolase, glycylleucine dipeptide hydrolase, non-specific dipeptidase, human cytosolic non-specific dipeptidase, glycyl-L-leucine hydrolase, glycyl-glycine dipeptidase

Summary:
This reaction is needed because automated instantiation of this case fails for the generic version a dipeptide + H2O → 2 a standard α amino acid.

Enzyme Commission Summary:
This enzyme catalyzes the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids. It is a zinc enzyme with broad specificity, varying somewhat with source species. Activated and stabilized by dithiothreitol and Mn2+. Inhibited by bestatin and leucine.

Relationship Links: BRENDA:EC:3.4.13.18 , ENZYME:EC:3.4.13.18 , IUBMB-ExplorEnz:EC:3.4.13.18

Credits:
Created 07-May-2012 by Krummenacker M , SRI International


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Fri Jul 31, 2015, biocyc13.