|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
In Pathway: inosine-5'-phosphate biosynthesis I
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 5-(carboxyamino)imidazole ribonucleotide mutase
Enzyme Commission Synonyms: N5-CAIR mutase, PurE, N5-carboxyaminoimidazole ribonucleotide mutase, class I PurE
Reversible reaction catalyzed by N5-carboxyaminoimidazole ribonucleotide mutase (PurE complex) [Meyer99].
Enzyme Commission Summary:
In eubacteria, fungi and plants, this enzyme, along with EC 22.214.171.124, is required to carry out the single reaction catalyzed by EC 126.96.36.199 in vertebrates. In the absence of EC 188.8.131.52, the reaction is reversible. The substrate is readily converted into 5-amino-1-(5-phospho-D ribosyl)imidazole by non-enzymic decarboxylation.
Firestine94: Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ (1994). "Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms." Biochemistry 1994;33(39);11927-34. PMID: 7918411
Firestine98: Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ (1998). "Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis." Arch Biochem Biophys 351(1);123-34. PMID: 9500840
Mathews99: Mathews II, Kappock TJ, Stubbe J, Ealick SE (1999). "Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway." Structure Fold Des 1999;7(11);1395-406. PMID: 10574791
Meyer92a: Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM (1992). "Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway." Biochemistry 1992;31(21);5022-32. PMID: 1534690
Meyer99: Meyer E, Kappock TJ, Osuji C, Stubbe J (1999). "Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase." Biochemistry 1999;38(10);3012-8. PMID: 10074353
Mueller94a: Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J (1994). "N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli." Biochemistry 1994;33(8);2269-78. PMID: 8117684
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