Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
shikimate dehydrogenase Inferred from experiment : aroE
shikimate dehydrogenase : ydiB

In Pathway: chorismate biosynthesis from 3-dehydroquinate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
shikimate + NAD(P)+ ← 3-dehydroshikimate + NAD(P)H + H+ (

Enzyme Commission Primary Name: shikimate dehydrogenase

Enzyme Commission Synonyms: dehydroshikimic reductase, shikimate oxidoreductase, shikimate:NADP+ oxidoreductase, 5-dehydroshikimate reductase, shikimate 5-dehydrogenase, 5-dehydroshikimic reductase, DHS reductase, shikimate:NADP+ 5-oxidoreductase, AroE

This is the fourth step in the shikimate pathway.

Enzyme Commission Summary:
NAD+ cannot replace NADP+ [Yaniv55]. In higher organisms, this enzyme forms part of a multienzyme complex with EC, 3-dehydroquinate dehydratase [Chaudhuri85].

Citations: [BALINSKY61, MITSUHASHI54a, Anton88, Ye03]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [shikimate + NAD(P)+ ← 3-dehydroshikimate + NAD(P)H + H+] (
i1: shikimate + NADP+ ↔ 3-dehydroshikimate + NADPH + H+ (

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Anton88: Anton IA, Coggins JR (1988). "Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase." Biochem J 1988;249(2);319-26. PMID: 3277621

BALINSKY61: BALINSKY D, DAVIES DD (1961). "Aromatic biosynthesis in higher plants. 1. Preparation and properties of dehydroshikimic reductase." Biochem J 80;292-6. PMID: 13686342

Chaudhuri85: Chaudhuri S, Coggins JR (1985). "The purification of shikimate dehydrogenase from Escherichia coli." Biochem J 1985;226(1);217-23. PMID: 3883995

MITSUHASHI54a: MITSUHASHI S, DAVIS BD (1954). "Aromatic biosynthesis. XIII. Conversion of quinic acid to 5-dehydroquinic acid by quinic dehydrogenase." Biochim Biophys Acta 15(2);268-80. PMID: 13208693

Yaniv55: Yaniv H, Gilvarg C (1955). "Aromatic biosynthesis. XIV. 5-Dehydroshikimic reductase." J Biol Chem 213(2);787-95. PMID: 14367339

Ye03: Ye S, Von Delft F, Brooun A, Knuth MW, Swanson RV, McRee DE (2003). "The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode." J Bacteriol 185(14);4144-51. PMID: 12837789

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Fri May 22, 2015, biocyc12.