|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
In Pathway: chorismate biosynthesis from 3-dehydroquinate
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Direct generic reaction:
shikimate + NAD(P)+ ← 3-dehydroshikimate + NAD(P)H + H+ (22.214.171.1242)
Enzyme Commission Primary Name: shikimate dehydrogenase
Enzyme Commission Synonyms: dehydroshikimic reductase, shikimate oxidoreductase, shikimate:NADP+ oxidoreductase, 5-dehydroshikimate reductase, shikimate 5-dehydrogenase, 5-dehydroshikimic reductase, DHS reductase, shikimate:NADP+ 5-oxidoreductase, AroE
This is the fourth step in the shikimate pathway.
Instance reaction of [shikimate + NAD(P)+ ← 3-dehydroshikimate + NAD(P)H + H+] (126.96.36.1992):
i1: shikimate + NADP+ ↔ 3-dehydroshikimate + NADPH + H+ (188.8.131.52)
MITSUHASHI54: MITSUHASHI S, DAVIS BD (1954). "Aromatic biosynthesis. XIII. Conversion of quinic acid to 5-dehydroquinic acid by quinic dehydrogenase." Biochim Biophys Acta 15(2);268-80. PMID: 13208693
Ye03: Ye S, Von Delft F, Brooun A, Knuth MW, Swanson RV, McRee DE (2003). "The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode." J Bacteriol 185(14);4144-51. PMID: 12837789
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