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Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
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Escherichia coli K-12 substr. MG1655 Reaction: 2.3.1.57

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.57

Enzymes and Genes:
spermidine acetyltransferase Inferred from experiment : speG

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
an aliphatic α,ω-diamine + acetyl-CoA = an aliphatic N-acetyl-diamine + coenzyme A + H+ (2.3.1.57)

Enzyme Commission Primary Name: diamine N-acetyltransferase

Enzyme Commission Synonyms: spermidine acetyltransferase, putrescine acetyltransferase, putrescine (diamine)-acetylating enzyme, diamine acetyltransferase, spermidine/spermine N1-acetyltransferase, spermidine N1-acetyltransferase, acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase, putrescine acetylase, putrescine N-acetyltransferase

Summary:
In this specific E.C. 2.3.1.57 reaction, spermidine is acetylated in response to cell stress.

Enzyme Commission Summary:
Acts on propane-1,3-diamine, pentane-1,5-diamine, putrescine, spermidine (forming N1- and N8-acetylspermidine), spermine, N1-acetylspermidine and N8-acetylspermidine.

Citations: [Ragione82]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.3.1.57 , ENZYME:EC:2.3.1.57 , IUBMB-ExplorEnz:EC:2.3.1.57


References

Ragione82: Ragione FD, Pegg AE (1982). "Purification and characterization of spermidine/spermine N1-acetyltransferase from rat liver." Biochemistry 21(24);6152-8. PMID: 7150547


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, biocyc13.