|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balance undetermined; a substrate lacks a chemical formula
In this reaction the inducer-binding protein TorT is bound to the inducer TMAO. This is the first step in the induction of the torCAD operon.
Expression of the torCAD operon encoding TMAO reductase requires three signal transducting steps involving TorT, a periplasmic inducer-binding protein, TorS, a sensor kinase-phosphotransferase, and TorR, a transcriptional regulatory protein. Experimental evidence suggests that TMAO binds with the TorT protein. This protein-ligand complex then interacts with the TorS sensor protein, possibly to activate it. Subsequently TorS further activated by autophosphorylation activates the transcriptional regulator, TorR. [Jourlin96a, Jourlin96]
Jourlin96: Jourlin C, Bengrine A, Chippaux M, Mejean V (1996). "An unorthodox sensor protein (TorS) mediates the induction of the tor structural genes in response to trimethylamine N-oxide in Escherichia coli." Mol Microbiol 1996;20(6);1297-306. PMID: 8809780
Jourlin96a: Jourlin C, Simon G, Pommier J, Chippaux M, Mejean V (1996). "The periplasmic TorT protein is required for trimethylamine N-oxide reductase gene induction in Escherichia coli." J Bacteriol 1996;178(4);1219-23. PMID: 8576063
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