Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Summary:
In this reaction the inducer-binding protein TorT is bound to the inducer TMAO. This is the first step in the induction of the torCAD operon.

Expression of the torCAD operon encoding TMAO reductase requires three signal transducting steps involving TorT, a periplasmic inducer-binding protein, TorS, a sensor kinase-phosphotransferase, and TorR, a transcriptional regulatory protein. Experimental evidence suggests that TMAO binds with the TorT protein. This protein-ligand complex then interacts with the TorS sensor protein, possibly to activate it. Subsequently TorS further activated by autophosphorylation activates the transcriptional regulator, TorR. [Jourlin96, Jourlin96a]


References

Jourlin96: Jourlin C, Simon G, Pommier J, Chippaux M, Mejean V (1996). "The periplasmic TorT protein is required for trimethylamine N-oxide reductase gene induction in Escherichia coli." J Bacteriol 1996;178(4);1219-23. PMID: 8576063

Jourlin96a: Jourlin C, Bengrine A, Chippaux M, Mejean V (1996). "An unorthodox sensor protein (TorS) mediates the induction of the tor structural genes in response to trimethylamine N-oxide in Escherichia coli." Mol Microbiol 1996;20(6);1297-306. PMID: 8809780


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13A.