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Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
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Escherichia coli K-12 substr. MG1655 Reaction: Transport of N-(2,3-dihydroxybenzoyl)-L-serine

Superclasses: Reactions Classified By Conversion Type Simple Reactions Transport Reactions Transport Reactions of Unknown Mechanism
Reactions Classified By Substrate Small-Molecule Reactions

Reaction Locations: extracellular space/cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Summary:
The activity of enterochelin esterase results in the hydrolysis of enterobactin into the linear trimer, dimer and monomer of 2,3 dihydroxybenzoyl serine. An E.coli entS mutant is unable to secrete enterobactin efficiently but does have elevated levels of enterobactin breakdown products in the culture medium. Dihydroxybenzoyl serine is able to stimulate the growth of E.coli under iron limiting conditions by acting as a siderophore [Furrer02].

Citations: [Hantke90a]

Credits:
Created 16-Feb-2010 by Mackie A , Macquarie University


References

Furrer02: Furrer JL, Sanders DN, Hook-Barnard IG, McIntosh MA (2002). "Export of the siderophore enterobactin in Escherichia coli: involvement of a 43 kDa membrane exporter." Mol Microbiol 44(5);1225-34. PMID: 12068807

Hantke90a: Hantke K (1990). "Dihydroxybenzoyl serine - a siderophore for E. coli." FEMS Microbiology Letters, 67, 5-8.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC14A.