Escherichia coli K-12 substr. MG1655 Reaction: transport of N-(2,3-dihydroxybenzoyl)-L-serine

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsTransport ReactionsTransport Reactions of Unknown Mechanism
Reactions Classified By SubstrateSmall-Molecule Reactions

Transport reaction diagram

Reaction Locations: extracellular space/cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

The activity of enterochelin esterase results in the hydrolysis of enterobactin into the linear trimer, dimer and monomer of 2,3 dihydroxybenzoyl serine. An E.coli entS mutant is unable to secrete enterobactin efficiently but does have elevated levels of enterobactin breakdown products in the culture medium. Dihydroxybenzoyl serine is able to stimulate the growth of E.coli under iron limiting conditions by acting as a siderophore [Furrer02].

Citations: [Hantke90]

Created 16-Feb-2010 by Mackie A, Macquarie University


Furrer02: Furrer JL, Sanders DN, Hook-Barnard IG, McIntosh MA (2002). "Export of the siderophore enterobactin in Escherichia coli: involvement of a 43 kDa membrane exporter." Mol Microbiol 44(5);1225-34. PMID: 12068807

Hantke90: Hantke K (1990). "Dihydroxybenzoyl serine - a siderophore for E. coli." FEMS Microbiology Letters, 67, 5-8.

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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