Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
UDP-N-acetylglucosamine enolpyruvoyl transferase Inferred from experiment : murA

In Pathway: UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Enzyme Commission Synonyms: MurA transferase, UDP-N-acetylglucosamine 1-carboxyvinyl-transferase, UDP-N-acetylglucosamine enoylpyruvyltransferase, enoylpyruvate transferase, phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase, phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase, phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase, phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase, phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase, pyruvate-UDP-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetyl-glucosamine transferase, pyruvic-uridine diphospho-N-acetylglucosaminyltransferase, phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase

This is the first committed step in peptidoglycan biosynthesis.

Citations: [vanHeijenoort01a, Zemell75, Gunetileke68]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Gunetileke68: Gunetileke KG, Anwar RA (1968). "Biosynthesis of uridine diphospho-N-acetylmuramic acid. II. Purification and properties of pyruvate-uridine diphospho-N-acetylglucosamine transferase and characterization of uridine diphospho-N-acetylenopyruvylglucosamine." J Biol Chem 243(21);5770-8. PMID: 5699062

vanHeijenoort01a: van Heijenoort J (2001). "Recent advances in the formation of the bacterial peptidoglycan monomer unit." Nat Prod Rep 18(5);503-19. PMID: 11699883

Zemell75: Zemell RI, Anwar RA (1975). "Pyruvate-uridine diphospho-N-acetylglucosamine transferase. Purification to homogeneity and feedback inhibition." J Biol Chem 250(8);3185-92. PMID: 1123336

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Fri Oct 9, 2015, biocyc13.