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Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number:

Enzymes and Genes:
ribonucleoside diphosphate reductase 1Inferred from experiment: nrdA, nrdB

In Pathway: superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli), pyrimidine deoxyribonucleotides de novo biosynthesis I

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ribonucleoside-diphosphate reductase

Enzyme Commission Synonyms: ribonucleotide reductase, CDP reductase, ribonucleoside diphosphate reductase, UDP reductase, ADP reductase, nucleoside diphosphate reductase, ribonucleoside 5'-diphosphate reductase, ribonucleotide diphosphate reductase, 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase, RR

Necessary for DNA synthesis.

Enzyme Commission Summary:
This enzyme is responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair. An iron protein. While the enzyme is activated by ATP, it is inhibited by dATP [Larsson66, Qiu06].

Citations: [Moore66, Larsson66a, Larsson73]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Larsson66: Larsson A, Reichard P (1966). "Enzymatic synthesis of deoxyribonucleotides. IX. Allosteric effects in the reduction of pyrimidine ribonucleotides by the ribonucleoside diphosphate reductase system of Escherichia coli." J Biol Chem 241(11);2533-9. PMID: 5330119

Larsson66a: Larsson A, Reichard P (1966). "Enzymatic synthesis of deoxyribonucleotides. X. Reduction of purine ribonucleotides; allosteric behavior and substrate specificity of the enzyme system from Escherichia coli B." J Biol Chem 241(11);2540-9. PMID: 5330120

Larsson73: Larsson A (1973). "Ribonucleotide reductase from regenerating rat liver. II. Substrate phosphorylation level and effect of deoxyadenosine triphosphate." Biochim Biophys Acta 324(4);447-51. PMID: 4543472

Moore66: Moore EC, Hurlbert RB (1966). "Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors." J Biol Chem 241(20);4802-9. PMID: 5926184

Qiu06: Qiu W, Zhou B, Darwish D, Shao J, Yen Y (2006). "Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits." Biochem Biophys Res Commun 340(2);428-34. PMID: 16376858

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc13.