Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
twitter

Escherichia coli K-12 substr. MG1655 Reaction: 4.1.1.37

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.37

Enzymes and Genes:
uroporphyrinogen decarboxylase Inferred from experiment : hemE

In Pathway: heme biosynthesis I (aerobic) , superpathway of heme biosynthesis from uroporphyrinogen-III , heme biosynthesis II (anaerobic)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: uroporphyrinogen decarboxylase

Enzyme Commission Synonyms: uroporphyrinogen III decarboxylase, porphyrinogen carboxy-lyase, porphyrinogen decarboxylase, uroporphyrinogen-III carboxy-lyase

Summary:
A reaction in porphyrin biosynthesis.

Enzyme Commission Summary:
Acts on a number of porphyrinogens.

Citations: [MAUZERALL58, Tomio70]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:4.1.1.37 , ENZYME:EC:4.1.1.37 , IUBMB-ExplorEnz:EC:4.1.1.37


References

MAUZERALL58: MAUZERALL D, GRANICK S (1958). "Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase." J Biol Chem 232(2);1141-62. PMID: 13549492

Tomio70: Tomio JM, Garcia RC, San Martin de Viale LC, Grinstein M (1970). "Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes. Purification and properties." Biochim Biophys Acta 198(2);353-63. PMID: 4984554


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Tue Sep 1, 2015, BIOCYC14B.