Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
uroporphyrinogen decarboxylase Inferred from experiment : hemE

In Pathway: heme biosynthesis I (aerobic) , superpathway of heme biosynthesis from uroporphyrinogen-III , heme biosynthesis II (anaerobic)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: uroporphyrinogen decarboxylase

Enzyme Commission Synonyms: uroporphyrinogen III decarboxylase, porphyrinogen carboxy-lyase, porphyrinogen decarboxylase, uroporphyrinogen-III carboxy-lyase

A reaction in porphyrin biosynthesis.

Enzyme Commission Summary:
Acts on a number of porphyrinogens.

Citations: [MAUZERALL58, Tomio70]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


MAUZERALL58: MAUZERALL D, GRANICK S (1958). "Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase." J Biol Chem 232(2);1141-62. PMID: 13549492

Tomio70: Tomio JM, Garcia RC, San Martin de Viale LC, Grinstein M (1970). "Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes. Purification and properties." Biochim Biophys Acta 198(2);353-63. PMID: 4984554

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Thu Jul 30, 2015, biocyc12.