There is no gene identified for this enzyme. The subunit structure is unknown.
Synonyms: ketopantoyl lactone reductase, pantoyl-lactone:NADP+ oxidoreductase (B-specific)
EC Number: 18.104.22.168/22.214.171.124/126.96.36.1998(R)-pantolactone + NADP+ ⇄ 2-dehydropantolactone + NADPH + H+
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction of enzyme catalysis.
This reaction is reversible.
Note: The enzyme may catalyze this reaction in vitro, but this reaction is not considered to be physiologically relevant.Alternative Substrates for 2-dehydropantolactone: keto-ω-methylpantoyl lactone [Wilken75]
The physiological function of 2-dehydropantoyl-lactone reductase is unknown. However, it is clear that it does not participate in pantothenate biosynthesis. The E. coli enzyme is B-specific with respect to stereospecificity. [Wilken75, Neidhardt96]
Neidhardt96: Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low Jr KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE "Escherichia coli and Salmonella, Cellular and Molecular Biology, Second Edition." American Society for Microbiology, Washington, D.C., 1996.
Wilken75: Wilken DR, King HL, Dyar RE (1975). "Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate." J Biol Chem 1975;250(6);2311-4. PMID: 234966
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