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Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
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Escherichia coli K-12 substr. MG1655 Enzyme: 2-dehydropantoyl-lactone reductase

Summary:
There is no gene identified for this enzyme. The subunit structure is unknown.

Gene-Reaction Schematic: ?


Enzymatic reaction of: 2-dehydropantoyl-lactone reductase

Synonyms: ketopantoyl lactone reductase, pantoyl-lactone:NADP+ oxidoreductase (B-specific)

EC Number: 1.1.1.358

(R)-pantolactone + NADP+ <=> 2-dehydropantolactone + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.

Note: The enzyme may catalyze this reaction in vitro, but this reaction is not considered to be physiologically relevant.

Alternative Substrates for 2-dehydropantolactone: keto-ω-methylpantoyl lactone [Wilken75 ]

Summary:
The physiological function of 2-dehydropantoyl-lactone reductase is unknown. However, it is clear that it does not participate in pantothenate biosynthesis. The E. coli enzyme is B-specific with respect to stereospecificity. [Wilken75, Neidhardt96]


References

Neidhardt96: Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low Jr KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE "Escherichia coli and Salmonella, Cellular and Molecular Biology, Second Edition." American Society for Microbiology, Washington, D.C., 1996.

Wilken75: Wilken DR, King HL, Dyar RE (1975). "Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate." J Biol Chem 1975;250(6);2311-4. PMID: 234966


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Tue Nov 25, 2014, BIOCYC13A.