Escherichia coli K-12 substr. MG1655 Enzyme: guanylate cyclase

There is no gene identified with the enzyme yet.

Gene-Reaction Schematic

Gene-Reaction Schematic

Enzymatic reaction of: guanylate cyclase

Synonyms: guanylyl cyclase, guanyl cyclase, GTP pyrophosphate-lyase (cyclizing)

EC Number:

GTP ⇄ cyclic-GMP + diphosphate

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.

Guanylate cyclase catalyzes the synthesis of cyclic GMP. The enzyme is distinct from adenylate cyclase. [Macchia81] Its genetics are unknown.

Cofactors or Prosthetic Groups: Mn2+ [Comment 1]

Inhibitors (Unknown Mechanism): fluoride [Comment 2]


Macchia75: Macchia V, Varrone S, Weissbach H, Miller DL (1975). "Guanylate cyclase in Escherichia coli. Purification and properties." J Biol Chem 1975;250(16);6214-7. PMID: 239941

Macchia81: Macchia V, Caputo G, Mandato E, Rocino A, Adhya S, Pastan I (1981). "Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase." J Bacteriol 1981;147(3);931-4. PMID: 6115852

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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