Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Escherichia coli K-12 substr. MG1655 Enzyme: guanylate cyclase

Summary:
There is no gene identified with the enzyme yet.

Gene-Reaction Schematic: ?


Enzymatic reaction of: guanylate cyclase

Synonyms: guanylyl cyclase, guanyl cyclase, GTP pyrophosphate-lyase (cyclizing)

EC Number: 4.6.1.2

GTP <=> cyclic-GMP + diphosphate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.

Summary:
Guanylate cyclase catalyzes the synthesis of cyclic GMP. The enzyme is distinct from adenylate cyclase. [Macchia81] Its genetics are unknown.

Cofactors or Prosthetic Groups: Mn2+ [Comment 1]

Inhibitors (Unknown Mechanism): fluoride [Comment 2]


References

Macchia75: Macchia V, Varrone S, Weissbach H, Miller DL (1975). "Guanylate cyclase in Escherichia coli. Purification and properties." J Biol Chem 1975;250(16);6214-7. PMID: 239941

Macchia81: Macchia V, Caputo G, Mandato E, Rocino A, Adhya S, Pastan I (1981). "Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase." J Bacteriol 1981;147(3);931-4. PMID: 6115852


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC14B.