Escherichia coli K-12 substr. MG1655 Enzyme: guanylate cyclase

There is no gene identified with the enzyme yet.

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Enzymatic reaction of: guanylate cyclase

Synonyms: guanylyl cyclase, guanyl cyclase, GTP pyrophosphate-lyase (cyclizing)

EC Number:

GTP <=> cyclic-GMP + diphosphate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.

Guanylate cyclase catalyzes the synthesis of cyclic GMP. The enzyme is distinct from adenylate cyclase. [Macchia81] Its genetics are unknown.

Cofactors or Prosthetic Groups: Mn2+ [Comment 1]

Inhibitors (Unknown Mechanism): fluoride [Comment 2]


Macchia75: Macchia V, Varrone S, Weissbach H, Miller DL (1975). "Guanylate cyclase in Escherichia coli. Purification and properties." J Biol Chem 1975;250(16);6214-7. PMID: 239941

Macchia81: Macchia V, Caputo G, Mandato E, Rocino A, Adhya S, Pastan I (1981). "Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase." J Bacteriol 1981;147(3);931-4. PMID: 6115852

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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