There is no gene identified with the enzyme yet.
Synonyms: guanylyl cyclase, guanyl cyclase, GTP pyrophosphate-lyase (cyclizing)
EC Number: 22.214.171.124
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.
This reaction is reversible.
Guanylate cyclase catalyzes the synthesis of cyclic GMP. The enzyme is distinct from adenylate cyclase. [Macchia81] Its genetics are unknown.
Macchia81: Macchia V, Caputo G, Mandato E, Rocino A, Adhya S, Pastan I (1981). "Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase." J Bacteriol 1981;147(3);931-4. PMID: 6115852
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