There is no gene identified with the enzyme yet.
Synonyms: guanylyl cyclase, guanyl cyclase, GTP pyrophosphate-lyase (cyclizing)
EC Number: 220.127.116.11GTP ⇄ cyclic-GMP + diphosphate
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction of enzyme catalysis.
This reaction is reversible.
Guanylate cyclase catalyzes the synthesis of cyclic GMP. The enzyme is distinct from adenylate cyclase. [Macchia81] Its genetics are unknown.
Macchia81: Macchia V, Caputo G, Mandato E, Rocino A, Adhya S, Pastan I (1981). "Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase." J Bacteriol 1981;147(3);931-4. PMID: 6115852
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