PRPP may be synthesized from ribose 5-phosphate by PRPP synthase or, alternately, by the the enzymes phosphopentomutase, ribose 1-phosphokinase (putative), and ribose 1,5-bisphosphokinase [HoveJensen03].
As of May 2003, the identity of the gene (or genes) encoding ribose 1-phosphokinase is not known [HoveJensen03].
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
The reaction is favored in the direction shown.
HoveJensen03: Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL (2003). "Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways." J Bacteriol 185(9);2793-801. PMID: 12700258
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