Escherichia coli K-12 substr. MG1655 Enzyme: ribose 1-phosphokinase

PRPP may be synthesized from ribose 5-phosphate by PRPP synthase or, alternately, by the the enzymes phosphopentomutase, ribose 1-phosphokinase (putative), and ribose 1,5-bisphosphokinase [HoveJensen03].

As of May 2003, the identity of the gene (or genes) encoding ribose 1-phosphokinase is not known [HoveJensen03].

Gene-Reaction Schematic

Gene-Reaction Schematic

Enzymatic reaction of: ribose 1-phosphokinase

α-D-ribose-1-phosphate + ATP → α-D-ribose 1,5-bisphosphate + ADP + H+

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: superpathway of histidine, purine, and pyrimidine biosynthesis, PRPP biosynthesis II

Citations: [HoveJensen03 ]


HoveJensen03: Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL (2003). "Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways." J Bacteriol 185(9);2793-801. PMID: 12700258

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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