Escherichia coli K-12 substr. MG1655 Enzyme: ribose 1-phosphokinase

PRPP may be synthesized from ribose 5-phosphate by PRPP synthase or, alternately, by the the enzymes phosphopentomutase, ribose 1-phosphokinase (putative), and ribose 1,5-bisphosphokinase [HoveJensen03].

As of May 2003, the identity of the gene (or genes) encoding ribose 1-phosphokinase is not known [HoveJensen03].

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Enzymatic reaction of: ribose 1-phosphokinase

α-D-ribose-1-phosphate + ATP <=> α-D-ribose 1,5-bisphosphate + ADP + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: superpathway of histidine, purine, and pyrimidine biosynthesis , PRPP biosynthesis II

Citations: [HoveJensen03]


HoveJensen03: Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL (2003). "Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways." J Bacteriol 185(9);2793-801. PMID: 12700258

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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